Born into a circus family, Florence Lake and her younger brother Arthur Lake (later the star of the Blondie films) were performing on-stage before they knew how to read or write. Florence Lake began playing juvenile roles in films as early as 1916, occasionally appearing with Arthur in the Fox Kiddies series. She made her talkie debut in 1929, at first receiving sizeable supporting roles in such features as The Rogue Song (1930). By 1932, however, she was firmly established in two-reel comedies, appearing as the birdbrained, garrulous wife of Edgar Kennedy in a series of RKO Radio shorts which lasted until 1948. During this period she also essayed innumerable uncredited bits in features, usually playing a woebegone wallflower or motor-mouthed "best friend." In the early '50s, she could occasionally be seen in villainous roles on such TV series as The Lone Ranger. Active until the 1970s, Florence Lake made an unforgettable appearance as the octogenarian blind date of newly divorced Lou Grant (Edward Asner) on a 1973 episode of The Mary Tyler Moore Show.