A passionate small-screen player who often collaborates with her husband, actor-director-producer Ken Olin, Wettig appeared in a number of '80s series before landing her signature role as a cancer-stricken wife and mother on the seminal yuppie drama thirtysomething. During the show's four-year run, Wettig won a Golden Globe and three Emmys, acted alongside her husband (although they didn't play on-screen spouses) and made her film debut as an unstable movie star in Guilty by Suspicion. As Olin transitioned from actor to TV writer-director, he helped his wife snag recurring roles in a number of series (L.A. Doctors, Breaking News, Alias) but she enjoyed one of her highest-profile parts in years on a show he had nothing to do with: Prison Break, as the manipulative vice president of the United States. Her follow-up series, the ABC drama Brothers & Sisters, became a true family affair, with Olin producing, Olin and daughter Roxy costarring, and son Cliff writing. Taking a cue from her prolific spouse, she also pursued other artistic avenues besides acting, getting an MFA in playwriting and earning kudos for penning My Andy, about the relationship between Andy Warhol and his mother.