Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bart Simpson/Nelson Muntz/Todd Flanders/Ralph Wiggum/Kearney

Nancy Cartwright

Lisa Simpson (voice)

Yeardley Smith

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Himself

Ozzie Smith

Hyman Krustofsky (voice)

Jackie Mason

Lurleen Lumpkin

Beverly D'Angelo

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Herb Powell

Danny DeVito

Bart's Electronically Altered Voice

Steve Allen

Sideshow Bob (voice)

Kelsey Grammer

Nigel Tufnel

Christopher Guest

Himself

Neil Patrick Harris

Himself

Magic Johnson

Baboons (voice) / Santa's Little Helper / Mr. Teeny

Frank Welker

Himself

Joe Frazier

Himself

Chick Hearn

Himself

Wade Boggs

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

David St. Hubbins

Michael McKean

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Agnes Skinner (voice) / (voice) / Dolph (voice)

Tress MacNeille

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Football's Greatest Injuries Narrator

Larry McKay

Himself

Ken Griffey Jr.

Himself

Sting

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott*

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Himself

Don Mattingly

Norbert Gastell

Samantha Stanky

Kimmy Robertson

Truong Van Dinh

Lona Williams

Himself

Steven Tyler

Himself

Joe Perry

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Sandra Schwittau

Himself

Steve Sax

Himself

Tom Hamilton

Sabine Bohlmann

Himself

Mike Scioscia

Himself

Darryl Strawberry

Himself

Joey Kramer

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Himself

Roger Clemens

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Himself

Jose Canseco

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Mona Simpson (voice)

Glenn Close

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Rayshelle Peyton (voice)

Kerry Washington

Milhouse Van Houten (voice)

Kelly Macleod

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow