Hank Hill

Mike Judge

Peggy Hill (voice)

Kathy Najimy

Bobby Hill

Pamela Segall

Luanne Platter (voice)

Brittany Murphy

Dale Gribble

Johnny Hardwick

Bill Dauterive (voice)

Stephen Root

Enrique (voice) / (voice)

Eloy Casados

Minh Souphanousinphone/Kahn 'Connie' Souphanousinphone Jr.

Lauren Tom

Gracie

Mary Scheer

Dr. Morley

Steven Banks

John Redcorn

Victor Aaron

Cissy Cobb

Laurie Metcalf

Guest Voice

Willie Nelson

Dale Gribble / Cotton Hill / Kahn Souphanousinphone (voice)

Toby Huss

Nancy Hicks Gribble (voice)

Ashley Gardner

C. Everett Koop

Jim Cummings

Guest Voice

Dennis Hopper

Randy Miller (voice) / (voice) / Velma Throckmorton (voice)

Cheryl Holliday

Case Manager

Gailard Sartain

Miss Kremzer

Jennifer Coolidge

Sharona Johnson

Dawnn Lewis

(voice) / Buckley (voice) / Jimmy Witchard (voice)

David Herman

Chuck Mangione (voice)

Chuck Mangione

Joseph Gribble (voice) / (voice) / Joseph Gribble

Breckin Meyer

John Redcorn (voice) / John Redcorn / Driver #2 (voice)

Jonathan Joss

Principal Moss (voice) / (voice) / Principal Moss

Dennis Burkley

(voice) / Mikey / Randy

Scott Klace

Lucky (voice) / Lucky / Mud Dobber (voice)

Tom Petty

(voice) / Burl Arlington / Harv Judd

Phil Hendrie

(voice) / Roger 'Booda' Sack (voice) / Vietnam War Veteran (voice)

Phil LaMarr

Enrique (voice) / (voice) / Lifeguard

Danny Trejo

Lane Pratley (voice) / (voice) / Toothless Loser (voice)

Dave Thomas

(voice) / Nguc Phong (voice) / Doctor (voice)

James Sie

Kahn Souphanousinphone

Ronny Chieng

Nurse (voice) / Tilly Hill (voice) / (voice)

Beth Grant

(voice) / Kahn's Boss (voice) / Football Kid (voice)

Glenn L. Lucas

Customer (voice) / Rollo / Coach (voice)

Randal Reeder

Maddy Platter (voice) / Marie's Mother (voice) / Nurse (voice)

Joanna Gleason

(voice) / Professor John Lerner (voice) / Fire Chief

Maurice LaMarche

Bob Jenkins (voice) / Bob Jenkins / Travis (voice)

Henry Gibson

Officer Brown (voice) / Ranger Bradley / Reclining Hippie (voice)

Fred Willard

Eric (voice) / Billy (voice) / James (voice)

Tara Strong

Emily (voice) / (voice) / Emily

Ashley Johnson

Mr. Holloway (voice) / Clerk (voice) / Sergeant Barber (voice)

Billy West

Mrs. Kalaiki-Alii (voice) / Michiko (voice) / Mrs. Laoma Souphanousinphone (voice)

Amy Hill

Chris Sizemore (voice) / Rob Holguin (voice) / Ed Burnett (voice)

Chris Elliott

Kenny (voice) / Caleb (voice) / Arrow Kid #2

Paul Butcher

Jane (voice) / Olivia (voice) / Dawn (voice)

Rini Bell

(voice) / Cameraman / Dr. Stephens (voice)

Wyatt Cenac