Captain Ed Mercer

Seth MacFarlane

Commander Kelly Grayson

Adrianne Palicki

Dr. Claire Finn

Penny Johnson Jerald

Lieutenant Gordon Malloy

Scott Grimes

Isaac

Mark Jackson

Lieutenant Commander Bortus

Peter Macon

Lieutenant Talla Keyali

Jessica Szohr

Chief Security Officer Alara Kitan

Halston Sage

John LaMarr

J. Lee Morgan

Lieutenant John Lamarr

J. Lee

Yaphit (voice)

Norm Macdonald

Klyden

Chad L. Coleman

Olix

Jason Alexander

Dann

Mike Henry

Laura

Leighton Meester

Admiral Ozawa

Kelly Hu

Teleya / Lt. Janel Tyler

Michaela McManus

Cassius

Chris Johnson

Marcus Finn

BJ Tanner

Ty Finn

Kai Wener

Mooska

Will Sasso

Admiral Halsey

Victor Garber

Marcus Finn

Brian Tanner

Charly Burke

Anne Winters

Lieutenant Turco / Ensign Turco

Kyra Santoro

Computer (voice)

Rachael MacFarlane

Steve Newton

Larry Joe Campbell

Topa

Blesson Yates

Brosk

Jim Mahoney

Kaylon Primary / Kaylon / K-1

Graham Hamilton

Minister Theece

Lesley Fera

Admiral Perry

Ted Danson

Altox

Michael C. Mahon

Simulated Moclan

Darren Dupree Washington

Moclan Prison Guard

Jude B. Lanston

Nurse Hopkins

Sarah Jane MacKay

Henry Park

Gavin Lee

Moclan Doctor

Joseph H. Johnson Jr.

Moclan #1

Michael James Lazar

Moclan #2

Torrance Jordan

Crew Member

Aaron McPherson

Officer

Iba Amar