Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bart Simpson / Nelson Muntz / Ralph Wiggum (voice)

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

David Silverman

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Norbert Gastell

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Himself

Weird Al Yankovic

Elisabeth Volkmann

Himself

Tony Bennett

Himself

David Byrne

Squiggy

David Lander

Himself

Tony Hawk

Batman

Adam West

Declan Desmond

Eric Idle

Himself

Ken Burns

Himself

James L. Brooks

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Himself

Little Richard

Ruth Powers

Pamela Reed

Himself

Elliott Gould

Sideshow Bob (voice)

Kelsey Grammer

Himself

George Plimpton

Himself

Mick Jagger

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Himself

Keith Richards

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Luke Stetson

Jonathan Taylor Thomas

Robin

Burt Ward

Himself

Larry Holmes

Sara Sloane

Marisa Tomei

Sandra Schwittau

Herself

Lisa Leslie

Himself

Steve Buscemi

Grady

Scott Thompson

Agnes Skinner (voice) / (voice) / Dolph (voice)

Tress MacNeille

Himself

Jackson Browne

Themselves

Blink 182

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Himself

Ben Schatz

Sabine Bohlmann

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Cleanie

Andy Serkis

Various Animals

John Kassir

Himself

Lenny Kravitz

Himself

Travis Barker

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Himself

Elvis Costello

Herself

Helen Fielding

Himeslf (Baha Men)

Rick Carey

Various

Terry W. Greene

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Additional Vocals

Sally Stevens

Himself

Tom Delonge

Himself

Tom Petty

Himself (Baha Men)

Omerit Hiedl

Himself

Brian Setzer

Himself

Mark Hoppus

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Himself (Baha Men)

Marvin Prosper

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott*

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Mona Simpson (voice)

Glenn Close

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Hyman Krustofsky (voice)

Jackie Mason

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Rayshelle Peyton (voice)

Kerry Washington

Milhouse Van Houten (voice)

Kelly Macleod

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Baboons (voice) / Santa's Little Helper / Mr. Teeny

Frank Welker

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow