Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Gloria

Julia Louis-Dreyfus

Himself

Weird Al Yankovic

Agnes Skinner (voice) / Dolph (voice) / (voice)

Tress MacNeille

Mary Spuckler

Zooey Deschanel

Donny

Topher Grace

Julia

Maya Rudolph

Milhouse Van Houten

Pamela Hayden

Colby Krause

Stephen Colbert

Mona Simpson (voice)

Glenn Close

Lurleen Lumpkin

Beverly D'Angelo

Himself

John C. Reilly

Sideshow Bob (voice)

Kelsey Grammer

Himself

Drew Carey

Himself

Jon Stewart

Herself

Terry Gross

Cecil Terwilliger

David Hyde Pierce

Himself

Lionel Richie

Additional Voices (voice) / (voice) / New England Church Members (voice)

Karl Wiedergott*

Herself as The Dixie Chicks

Natalie Maines

Maude Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)

Maggie Roswell

Himself

Lance Armstrong

Himself

Dan Rather

Himself

Jim Jarmusch

Dwight

Steve Buscemi

Himself

Placido Domingo

Himself

Kurt Loder

Himself

Ted Nugent

Martin Prince / Sherri / Terri / Additional Voices

Russi Taylor

Dr. Robert Terwilliger, Sr.

John Mahoney

Louie

Matt Dillon

Herself as The Dixie Chicks

Emily Robison

Chuck Sheetz

Edna Krabappel (voice) / Edna Krabappel / Ms. Melon (voice)

Marcia Wallace

Himself

Keith Olbermann

Herself as The Dixie Chicks

Martie Maguire

Alf Clausen

James L. Brooks

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Milo

Jack Black

Additional vocals

Michael Dees

Marc Wilmore

Himself

Dan Clowes

Alan Decker

Himself

Alan Moore

Norbert Gastell

Dr. Hibbert (voice) / Narrator (voice) / Security Guard (voice)

Kevin Michael Richardson

Himself

Art Spiegelman

Elisabeth Volkmann

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Orson Welles (voice) / (voice) / Jock #2 (voice)

Maurice LaMarche

Sandra Schwittau

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Korean Singer

Sang Am Lee

Sabine Bohlmann

Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Bernice Hibbert (voice) / (voice) / Flight Attendant (voice)

Dawnn Lewis

Llewellyn Sinclair (voice) / Enrico Irritazio (voice) / Artie Ziff (voice)

Jon Lovitz

Kumiko Albertson (voice) / Truth-Anne (voice) / "It Will Get Better" Girl (voice)

Jenny Yokobori

Hyman Krustofsky (voice)

Jackie Mason

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Jacques (voice) / Hank Scorpio (voice) / Brad Goodman (voice)

Albert Brooks

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Janine Powell (voice) / Lewis Clark (voice) / Lewis (voice)

Kimberly Brooks

Julio (voice) / Julio Franco (voice) / Audience

Tony Rodriguez

Lunchlady Doris (voice) / Ice cream lady (voice) / Lunchlady (voice)

Doris Grau

Weasel (voice) / Richard / Lewis (voice)

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Rayshelle Peyton (voice)

Kerry Washington

Backstage Mom (voice) / Ms. Myles (voice) / Jennifer Clarkeson (voice)

Valerie Harper

Lord Nibbler (voice) / Baboons (voice) / Santa's Little Helper

Frank Welker

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Murphy (voice) / Dana Gould (voice) / I.N.S. Agent (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Clayton (voice) / Nigel (voice)

Michael York

Bumblebee Man (voice) / Lisa's Student (voice) / Gambling Old Man (voice)

Eric Lopez

Stephen Hawking (voice)

Stephen Hawking

Sarah Wiggum (voice)

Megan Mullally

Waiter (voice) / Akira Kurosawa (voice) / Sushi Chef (voice)

George Takei

JJ Gruff (voice) / J. Jonah Jameson (voice) / Dr. Jessup (voice)

J.K. Simmons

Director

Mark Kirkland

Director

Neil Affleck

Director

Chuck Sheetz

Director

David Silverman

Director

Lauren MacMullan

Director

Dominic Polcino

Director

Swinton O. Scott III

Director

Rich Moore

Director

Raymond S. Persi

Director

Debbie Bruce Mahan

Director

Pete Michels

Director

Jennifer Moeller

Director

Mike B. Anderson

Director

Matthew Faughnan

Director

Michael Polcino