Daniel's `'Boss'`

Whoopi Goldberg

Daniel

David Arquette

Kermit the Frog / Rizzo the Rat / Beaker

Steve Whitmire

Bitterman

Joan Cusack

The Great Gonzo / Dr. Bunsen Honeydew / Waldorf

Dave Goelz

Pepe the King Prawn / Bobo the Bear / Johnny Fiama

Bill Barretta

Glenn

William H. Macy

Carson Daly

Carson Daly

Miss Piggy / Fozzie Bear / Animal

Eric Jacobson

Herself

Kelly Ripa

Jon Stewart

Jon Stewart

Herself - Cameo Appearance

Molly Shannon

Luc Fromage

Matthew Lillard

Rachel Hunter

Himself - Cameo Appearance

Joe Rogan

Dr. John J.D. Dorian

Zach Braff

Dr. Elliot Reed

Sarah Chalke

Dr. Perry Cox

John C. McGinley

Dr. Chris Turk

Donald Adeosun Faison

Janitor

Neil Flynn

Joe Snow

Mel Brooks

Nurse Carla Espinosa

Judy Reyes

Sam the Eagle

Frank Oz

Sally Ann Santa Claus

Dave Ward

Scooter / Janice / Sal Minella (voice)

Brian Henson

Sam Eagle (voice)

Kevin Clash

Executive Assistant

Conan Graham

Sweetums (voice)

John Henson

Robin the Frog / Statler / Announcer

Jerry Nelson

Uncle Nicky Nut-What

Robin Mossley

Eugene the Tuba Player (voice)

Allan Trautman

Handsome Executive

Dan Payne

Muppet Performer

Drew Massey

Michael Caine

Dr. Teeth (voice)

John E. Kennedy

Fear Factor Contestant

Dawn Lewis

Security Guard

Colin Foo

Angel 1

Yee Jee Tso

Angel 2

Dan Joffre

Fat Angel

Jonathan Bruce

Safari Animal Tracker

Cameron McDonald

Thin Angel

Darrell Lee-Izeard

Nancy Nut-What

Chantal Strand

Sally Ann Representative

Julia Arkos

Triumph

Robert Smigel

Director

Kirk R. Thatcher