Dr. Frasier Crane

Kelsey Grammer

Dr. Niles Crane

David Hyde Pierce

Martin Crane

John Mahoney

Daphne Moon

Jane Leeves

Roz Doyle

Peri Gilpin

Dr. Shafer

Daniel Davis

Trish Haney

Ana Gasteyer

Leland Barton

David Ogden Stiers

Kenny Daly

Tom McGowan

Gertrude Moon

Millicent Martin

Receptionist

Hal Sparks

Jen

Zooey Deschanel

Paul

Marc Vann

Dr. Phil

Phil McGraw

Chelsea

Jeanne Tripplehorn

Petyr

John Vickery

Rick

Dean Cain

Ben

Elvis Costello

Frederick Crane

Trevor Einhorn

George

Luis Guzmán

Julia Wilcox

Felicity Huffman

Twinkle

Kaileigh Martin

Dr. Lilith Sternin

Bebe Neuwirth

Dean of Admissions

Linden Chiles

Tow Truck Driver

Morocco Omari

Mrs. Richman / Mother in Elevator

Brooks Almy

Reservationist

Sarah Shahi

Bank President

Michael Winters

Ahmrit

Alan Cumming

Grant

John Turturro

Colleen

Judith Scott

Donny Douglas

Saul Rubinek

Mr. Grant

Timothy Carhart

Avery McManus

John Hannah

Coach Fuller

Bob Hoskins

Bebe Glazer

Harriet Sansom Harris

Mike Shaw

Harve Presnell

Doctor

Joseph Kell

Bulldog Briscoe

Dan Butler

Admissions Officer

David St. James

Facialist

Monica McSwain

Mrs. Grant

Dale Dickey

Woody Wiswell Jr.

David Alan Basche

Trudy

Mary Kowalski

Cora Winston

Emily Yancy

Robert

François Giroday

Dr. Ling

Denise Iketani

Reno Officiant

Sam Johnson*

Albert

Conrad Janis

Antonia

Ann Cusack

Jerry

Billy Bean

Stu

Bradley Whitford

Rabbi Gendler

Corey Fischer

Attendant

W. Scott Strassner

Red

Dennis Cockrum

Gil Chesterton

Edward Hibbert

Principal

Holmes Osborne

Supervisor

Rick Fitts

Albert

Brent Spiner

Old Frasier

Jack Axelrod

Evelyn

Alex Borstein

Mark

Charles Busch

Bank Manager

Shannon Cochran

Surgical Nurse

Alice Dodd

Jerry

John Wesley

Jason White

Steven Anthony Lawrence

Waitress

Amita Balla

Jim

Jack Brewer

The Other Niles

Dominic Rambaran

Judge Anderson

Ron Canada

Charlotte Connor / Mindy (voice)

Laura Linney

Alex

Paul Schulze

Alice May Doyle

Ashley Thomas

Margie

Hanna Watanabe

Campbell

Amanda Corday

Guy in Waiting Room

Kevin Chamberlin

Jeremy

Scotch Ellis Loring

Wayne

Dan Gerrity

Donald

JD Cullum

Judge Anderson

Hira Ambrosino

Swinger

Don Tiffany

Esthetician

Annie Wersching

Noel Shempsky

Patrick Kerr

Jeremy Berman

Brendan Hill

Old Daphne

Jean Sincere

Vladimir

Oleg Stefan

The Other Daphne

Robyn Johanna

Orderly 1

Steve Kehela

Bike Clerk

Mario Prado Jr.

James

James Oliver

Van

Mike Judge

Maureen Nervosa

Amy Hill

Sheila

Leelee Sobieski

Steve

Paul F. Tompkins

Team Leader Ronnie

Jordan Lund

Teller 1

Devlin Elliott

Mitch

Keith Sellon-Wright

Jason

Stephon Fuller

Coffee Guy

Matt Besser

Thad

Matthew Yang King

Orderly 2

Brandon Johnson

Beverly

Kathe Mazur

Cecilia

Marilyn Tokuda

Bridget

Twink Caplan

Nurse

Kelli Kirkland

Customs Officer

Sal Rendino

Sandy

Misha Henson

Plumber

Kendall Clement

Courier

Emory Livers III

Flight Attendant

Laurel Green

Ernie

Bill Paxton

Bill

Christopher Lawford

Steve

Kevin Daniels

Customer

Elizabeth Liang

Todd

Zachary W. Kranzler

Mr. Michaels

J. Kenneth Campbell

Mrs. Michaels

Sarah Brooke

James

James Aaron Oliver

Sharon

Nana Visitor

Mr. Slobodkin

Booth Colman

Zombie 2

Darion Basco

Mel Karnofsky

Jane Adams

Ice Sculptor

Michael Weston

Alice Doyle

Ashley Thomas

Luke

Joshua Fardon

Ronee Lawrence

Wendie Malick

Waitress

Luck Hari

Simon Moon

Anthony LaPaglia

Sherry Dempsey

Marsha Mason

Lana Gardner / Lorna Lynley

Jean Smart

Kirby Gardner

Brian Klugman

Kate Costas

Mercedes Ruehl

Director

David Lee

Director

Jeff Melman

Director

Wil Shriner

Director

Sheldon Epps

Director

David Lee

Director

Katy Garretson

Director

Philip Charles MacKenzie

Director

Kelsey Grammer

Director

Jerry Zaks

Director

James Burrows

Director

Scott Ellis

Director

Pamela Fryman