Lucas Scott

Chad Michael Murray

Nathan Scott

James Lafferty

Peyton Sawyer

Hilarie Burton

Haley James Scott

Bethany Joy Lenz

Dan Scott

Paul Johansson

Brooke Davis

Sophia Bush

Coach Brian "Whitey" Durham

Barry Corbin

Marvin `Mouth' McFadden

Lee Norris

Karen Roe

Moira Kelly

Keith Scott

Craig Sheffer

Reagan

Samantha Shelton

Antwon 'Skills' Taylor

Antwon Tanner

Jamie Scott

Jackson Brundage

Deb Scott

Barbara Alyn Woods

Guest Star

Sam Horrigan

Guest Star

Terry Horton

Guest Star

Gerald McRaney

Guest Star

Dave Power

Guest Star

Mike Erwin

Guest Star

Gavin DeGraw

Guest Star

Joan Severance

Guest Star

Paula Trickey

Millicent Huxtable

Lisa Goldstein

Guest Star

Brett Claywell

Guest Star

Emmanuelle Vaugier

Jeff Nelson

Cedric Pendleton

Guest Star

Blake Bashoff

Guest Star

Andrew Seeley

Guest Star

Jon Stafford

Guest Star

Tess Harper

Principal Turner

Shawn Shepard

Larry Sawyer

Thomas Ian Griffith

Guest Star

Ann Cusack

Guest Star

Sean Faris

Jake Jagielski

Bryan Greenberg

Guest Star

Corri English

Edwards

Colin Fickes

Guest Star

Dorothy Recastner Brown

Guest Star

Amy Parrish

Guest Star

Sarah Edwards

Dr. Milford

Terry Loughlin

Guest Star

Austin Carty

Guest Star

Tracy Williams

Guest Star

Jennifer Massey

Guest Star

Jason Saucier

Guest Star

Dan Becker

Guest Star

Cullen Moss

Guest Star

Sheryl Crow

Fergie Thompson

Vaughn Wilson

Guest Star

Mike Pniewski

Julian Baker

Austin Nichols

Guest Star

Melissa Claire Egan

Guest Star

Nancy Moreno

Guest Star

Erin Cline

Guest Star

Mark Ellis

Mr. Kelly

Jason Davis

Clay Evans

Robert Buckley

Officer Wayman

John Keenan

Quinn James

Shantel VanSanten

Brandon

Corey Jackson

Chase Adams

Stephen Colletti

Rachel

Rhoda Griffis

Rachel Gatina

Danneel Ackles

Alice

Melissa Ponzio

Pretty Girl

Leigh Jones

Kid

Marc Tschudi

Alex Dupre

Jana Kramer

Victoria Davis

Daphne Zuniga

Bevin

Bevin Prince

Mia Catalano

Kate Voegele

Chuck

Michael May

Chris Keller

Tyler Hilton

Lauren

Allison Munn

Jerry

Bradley Evans

Sam Walker

Ashley Rickards

Andy Hargrove

Kieren Hutchison

Gigi

Kelsey Asbille

Lindsey Strauss

Michaela McManus

Quentin Fields

Robbie Jones

Madison

Katherine Landry

Carrie

Torrey DeVitto

Owen Morello

Joe Manganiello

Felix Taggaro

Michael Copon

Anna Taggaro

Daniella Alonso

Paul Norris

Gregory Harrison

Miranda Stone

India de Beaufort

Katie / Sara

Amanda Schull

Jules

Maria Menounos

Grubbs

Michael Grubbs

Alexander Coyne

Mitch Ryan

Ellie Harp

Sheryl Lee

Andre

Jaden Harmon

Taylor James

Lindsey McKeon

Bobby

Burgess Jenkins

Derek

Matt Barr

David Fletcher

Scott Holroyd

Renee

Kate French

Rick

William Haze

Xavier / Man

Devin McGee

Logan

Pierce Gagnon

Dr. Hudson / KiKi

Jessica Lucas

Josh

Paul Teal

Erin

Laura Izibor

Derek Sommers

Ernest Waddell

Larry Sawyer

Kevin Kilner

Shelley Simon

Elisabeth Harnois

Cooper Lee

Michael Trucco

Ted Davis

Richard Burgi

Billy

Manu Intiraymi

Pablo Alvarez

David Norona

Jack Daniels

Evan Peters

Mrs. Skolnick

Kelley Davis

Sylvia Baker

Sharon Lawrence

August Kellerman

Peter Riegert

Erica Marsh

Katherine Bailess

Lydia James

Bess Armstrong

Tara Richards

Chelsea Kane

Devon Fox / Ref

B.J. Britt

Reeves / Detective

David Bridgewater

Glenda

Amber Wallace

Alice

Kelly Collins Lintz

Kylie

Sasha Jackson

Young Keith

Patrick Stogner

Birth Mom / Bustier Woman / Waitress

Juliet Cesario

Ian Kellerman

Eric McIntire

Officer Stevens / Assistant

Stephen Elliott