Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Agnes Skinner (voice) / (voice) / Dolph (voice)

Tress MacNeille

Walter Hottenhoffer

Werner Herzog

Edmund

Daniel Radcliffe

Himself

James Lipton

Himself

Ricky Gervais

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Taffy

Kristen Schaal

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Himself

Jemaine Clement

Dr. Zander

Paul Rudd

Herself

Danica Patrick

Cheech

Cheech Marin

Himself

Mark Zuckerberg

Himself

Mike Scioscia

Herself

Martha Stewart

The Great Raymondo

Martin Landau

Melody Juniper

Alyson Hannigan

Herself

Halle Berry

Himself

David Mamet

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott*

FBI Investigator

Jon Hamm

Himself

Kareem Abdul-Jabbar

Ewell Freestone

Jack McBrayer

Kurt

Bret McKenzie

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Herself

Katy Perry

Himself

Bill James

Himself

Muhammad Yunus

Himself

Joey Kramer

Grady

Scott Thompson

Dr. Thurmond

Rachel Weisz

Chong

Tommy Chong

Roger

Hugh Laurie

Herself

Lea Michele

Himself

Chris Hansen

Himself

Ken Burns

Calliope Juniper

Kristen Wiig

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Chinese Agent

Michael Paul Chan

Himself

Russell Brand

Himself

Ricky Jay

Norbert Gastell

Himself

David Copperfield

Additional Voices

Gregg Berger

Himself

Nick Park

Sheldon Leavitt

Garry Marshall

Himself

Cory Monteith

Walla Walla

Diane Michelle

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

DJ Kwanzaa

J.B. Smoove

Anke Engelke

Herself

Amber Riley

Penn

Penn Jillette

Teller

Teller

Himself

Ira Glass

Sandra Schwittau

Stephen Hawking (voice)

Stephen Hawking

Additional Voices

Terry W. Greene

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Terry Greene

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Sideshow Bob (voice)

Kelsey Grammer

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Mona Simpson (voice)

Glenn Close

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Hyman Krustofsky (voice)

Jackie Mason

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Rayshelle Peyton (voice)

Kerry Washington

Milhouse Van Houten (voice)

Kelly Macleod

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Baboons (voice) / Santa's Little Helper / Mr. Teeny

Frank Welker

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow