Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bart Simpson / Nelson Muntz / Ralph Wiggum (voice)

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Seth

Martin Mull

Himself

Rupert Murdoch

Himself

Regis Philbin

Herself

Cyndi Lauper

Astrid Weller

Isabella Rossellini

Agnes Skinner (voice) / (voice) / Dolph (voice)

Tress MacNeille

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Himself

Elton John

Himself

Jack LaLanne

Stephen Hawking (voice)

Stephen Hawking

Herself

Kim Basinger

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Voice

Marcia Wallace

Arthur Fortune / Jerry Rude

Michael McKean

Himself

Ed Begley Jr.

'Canyonero' Singer

Hank Williams Jr.

Himself / Leavelle

Mark Hamill

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

K.I.T.T.

William Daniels

Himself

Troy Aikman

Munchie

George Carlin

Himself

Alec Baldwin

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Himself

Jasper Johns

Herself

Kathie Lee Gifford

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Himself

Ed McMahon

Japanese Stewardess

Karen Maruyama

Himself

John Madden

Himself

Ron Howard

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott*

Japanese Father

Gedde Watanabe

Himself

Brian Grazer

Himself

Pat Summerall

Himself

Jerry Springer

Japanese Mother

Denice Kumagai

'Lost in Space' Robot

Dick Tufeld

Guest Voice

Yo La Tengo

Alex Whitney

Lisa Kudrow

Himself

Rosey Grier

Replacement Ned Flanders

Mike Scully

Himself

Dan Marino

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Possum

John Kassir

Himself

Frank Partipilo

Himself

Graeme Edge

Norbert Gastell

Herself

Dolly Parton

Freddy Kruger

Robert Englund

Himself

Justin Hayward

Wally Kogen

Fred Willard

Fish

Keone Young

Himself

John Lodge

Himself

Ray Thomas

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Sandra Schwittau

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Sideshow Bob (voice)

Kelsey Grammer

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Mona Simpson (voice)

Glenn Close

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Hyman Krustofsky (voice)

Jackie Mason

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Rayshelle Peyton (voice)

Kerry Washington

Milhouse Van Houten (voice)

Kelly Macleod

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Baboons (voice) / Santa's Little Helper / Mr. Teeny

Frank Welker

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow