Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Dolph

Tress MacNeille

Jack Bauer

Kiefer Sutherland

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Declan Desmond

Eric Idle

Ludacrest

Chris "Ludacris" Bridges

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Guest Voice

The White Stripes

Himself

Ronaldo

Darcy

Natalie Portman

Victor Kleskow (voice) / Dr. Jessup (voice) / Tabloid Editor (voice)

J.K. Simmons

Chloe O'Brian

Mary Lynn Rajskub

Himself

Gore Vidal

Himself

Harry Hamlin

Himself as The White Stripes

Jack White

Dante

Joe Pantoliano

Voice

Russi Taylor

Herself

Betty White

Dr. Phil

Dr. Phil McGraw

Herself as The White Stripes

Meg White

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Dr. Swanson

Meg Ryan

Himself

Michael Chabon

Dante Jr.

Michael Imperioli

Himself

Elvis Stojko

Golem

Richard Lewis

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Psychologist

Peter Bogdanovich

Waitress

Larina Adamson

Llewellyn Sinclair (voice) / Enrico Irritazio (voice) / Artie Ziff (voice)

Jon Lovitz

Himself

Tom Wolfe

Maude Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)

Maggie Roswell

Female Golem

Fran Drescher

Himself

Jonathan Franzen

Himself

James Patterson

Stephen Hawking (voice)

Stephen Hawking

Performer 'Baby Likes Fat'

Sir Mix-a-Lot

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Additional Voices

Sab Shimono

Himself

Andy Dick

Himself

Stephen Sondheim

Additional Voices (voice) / (voice) / Garbage Man (voice)

Karl Wiedergott*

Murphy (voice) / Dana Gould (voice) / I.N.S. Agent (voice)

Dana Gould

Norbert Gastell

Himself

Rudy Giuliani

Himself as Metallica

James Hetfield

Elisabeth Volkmann

Dr. Hibbert (voice) / Narrator (voice) / Security Guard (voice)

Kevin Michael Richardson

Himself as Metallica

Lars Ulrich

Sandra Schwittau

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Himself as Metallica

Kirk Hammett

Sabine Bohlmann

Himself as Metallica

Robert Trujillo

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Sideshow Bob (voice)

Kelsey Grammer

Bernice Hibbert (voice) / (voice) / Bernice Hibbert

Dawnn Lewis

Hyman Krustofsky (voice)

Jackie Mason

Mona Simpson (voice)

Glenn Close

Kumiko Albertson (voice) / Truth-Anne (voice) / Band Student (voice)

Jenny Yokobori

Helen Lovejoy (voice) / Maude Flanders (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Jacques (voice) / Hank Scorpio (voice) / Brad Goodman (voice)

Albert Brooks

Janine Powell (voice) / Lewis Clark (voice) / Kindergartener (voice)

Kimberly Brooks

Lunchlady Doris (voice) / Ice cream lady (voice) / Lunchlady (voice)

Doris Grau

Minnesota Girl / Maria Dominguez / Paper Boy (voice)

Jo Ann Harris

Julio (voice) / Julio Franco (voice) / Audience

Tony Rodriguez

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Rayshelle Peyton (voice)

Kerry Washington

Ms. Myles (voice) / Old Lady (voice) / Mrs. Butterworth (voice)

Valerie Harper

Tough Street Dog / Mean Zoo Animals (voice) / Lord Nibbler (voice)

Frank Welker

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Dr. Lionel Budgie (voice) / Clayton (voice) / Mason Fairbanks (voice)

Michael York

Bumblebee Man (voice) / Lisa's Student (voice) / Gambling Old Man (voice)

Eric Lopez

Sarah Wiggum (voice)

Megan Mullally

Wink - The Game Show Host (voice) / George Takei (voice) / Akira Kurosawa (voice)

George Takei

Director

Mark Kirkland

Director

Neil Affleck

Director

Chuck Sheetz

Director

David Silverman

Director

Lauren MacMullan

Director

Dominic Polcino

Director

Swinton O. Scott III

Director

Rich Moore

Director

Raymond S. Persi

Director

Pete Michels

Director

Jennifer Moeller

Director

Mike B. Anderson

Director

Michael Polcino