Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Dolph

Tress MacNeille

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Prof. Whistler

Nick Fascitelli

Baboons (voice) / Santa's Little Helper / Mr. Teeny

Frank Welker

Guthrie Frenel

Martin Short

Marge-Like Man

Nikolaj Coster-Waldau

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

Manacek

Bill Hader

Morty Szyslak

Ray Liotta

Trombonist

Trombone Shorty

Self

Shaquille O'Neal

Sun

Jimmy O. Yang

Irish Priest

Ben Daniels

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Self

Norman Lear

Self

Roz Chast

Ross/Bagel Man/Professor

Kevin Pollak

Minnie Szyslak

Debi Mazar

Self

Daniel Radcliffe

Michael Jackson

Kipp Lennon

Himself

Damian Kulash

Brendan

Ed Sheeran

Megan

Cecily Strong

Dr. Kenneth Humphries

William Friedkin

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Himself

Tim Nordwind

Self

Alison Bechdel

Himself

John Baldessari

Himself

Mario Batali

Salesman

Jonathan Schmock

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Self

Marjane Satrapi

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Christoph Jablonka

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott*

Self

Rachel Bloom

Anke Engelke

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Sandra Schwittau

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Sideshow Bob (voice)

Kelsey Grammer

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Mona Simpson (voice)

Glenn Close

Andrew Daly

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Hyman Krustofsky (voice)

Jackie Mason

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Rayshelle Peyton (voice)

Kerry Washington

Milhouse Van Houten (voice)

Kelly Macleod

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Stephen Hawking (voice)

Stephen Hawking

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow