Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Dolph

Tress MacNeille

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Prof. Whistler

Nick Fascitelli

Monkeys / Princess (voice) / Executive Vice-President (voice)

Frank Welker

Guthrie Frenel

Martin Short

Marge-Like Man

Nikolaj Coster-Waldau

Akira Kurosawa (voice) / Wink - The Game Show Host (voice) / Waiter (voice)

George Takei

Llewellyn Sinclair (voice) / Artie Ziff (voice) / Enrico Irritazio (voice)

Jon Lovitz

Manacek

Bill Hader

Morty Szyslak

Ray Liotta

Trombonist

Trombone Shorty

Self

Shaquille O'Neal

Sun

Jimmy O. Yang

Irish Priest

Ben Daniels

J. Jonah Jameson (voice) / Victor Kleskow (voice) / Tabloid Editor (voice)

J.K. Simmons

Self

Norman Lear

Self

Roz Chast

Ross/Bagel Man/Professor

Kevin Pollak

Minnie Szyslak

Debi Mazar

Self

Daniel Radcliffe

Michael Jackson

Kipp Lennon

Himself

Damian Kulash

Brendan

Ed Sheeran

Megan

Cecily Strong

Dr. Kenneth Humphries

William Friedkin

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Himself

Tim Nordwind

Self

Alison Bechdel

Himself

John Baldessari

Himself

Mario Batali

Salesman

Jonathan Schmock

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Self

Marjane Satrapi

Backstage Mom (voice) / Mrs. Butterworth (voice) / Old Lady (voice)

Valerie Harper

Christoph Jablonka

Additional Voices (voice) / (voice) / Prisoners

Karl Wiedergott*

Self

Rachel Bloom

Anke Engelke

Dr. Hibbert (voice) / Narrator (voice) / Jay G (voice)

Kevin Michael Richardson

Sandra Schwittau

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Sideshow Bob (voice)

Kelsey Grammer

Bernice Hibbert (voice) / (voice) / Cannabis Influencer (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / Chef Naziwa

Maurice LaMarche

Mona Simpson (voice)

Glenn Close

Kumiko Albertson (voice) / Truth-Anne (voice) / Band Student (voice)

Jenny Yokobori

Hyman Krustofsky (voice)

Jackie Mason

Andrew Daly

Helen Lovejoy (voice) / Maude Flanders (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Jacques (voice) / Hank Scorpio (voice) / Tab Spangler

Albert Brooks

Julio Franco (voice) / Julio (voice) / Audience

Tony Rodriguez

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Lewis Clark (voice) / Janine Powell (voice) / Kindergartener (voice)

Kimberly Brooks

Lunchlady Doris (voice) / Ice cream lady (voice) / Della (voice)

Doris Grau

Susan / Collette the Waitress (voice) / Weasel #2

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Rayshelle Peyton (voice)

Kerry Washington

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Murphy (voice) / Dana Gould (voice) / I.N.S. Agent (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Clayton (voice)

Michael York

Bumblebee Man (voice) / Lisa's Student (voice) / Gambling Old Man (voice)

Eric Lopez

Stephen Hawking (voice)

Stephen Hawking

Sarah Wiggum (voice)

Megan Mullally