Sam Winchester

Jared Padalecki

Dean Winchester

Jensen Ackles

Bobby Singer

Jim Beaver

Meg Masters

Nicki Aycox

Guest Star

Rob Benedict

Guest Star

Dameon Clarke

Castiel / Emmanuel / Jimmy Novak

Misha Collins

Guest Star

Genevieve Cortese

Adam Milligan / Michael

Jake Abel

Guest Star

John Rubinstein

Pamela Barnes

Traci Dinwiddie

Guest Star

Mark Rolston

Guest Star

Matthew Cohen

Guest Star

C. Malik Whitfield

Guest Star

Katherine Boecher

Anna Milton

Julie McNiven

Guest Star

Amy Gumenick

Guest Star

Barry Bostwick

Guest Star

Robert Wisdom

Guest Star

Richard Libertini

Guest Star

Christopher Heyerdahl

Crowley

Mark Sheppard

Guest Star

Kurt Fuller

Samuel Campbell / Shapeshifter

Mitch Pileggi

Rowena MacLeod

Ruth Connell

Jack / Belphegor

Alexander Calvert

Mary Winchester

Samantha Smith

Lucifer

Mark Pellegrino

Arthur Ketch

David Haydn-Jones

Jody Mills

Kim Rhodes

Amara / Amara (Adult) / Karin

Emily Swallow

Metatron

Curtis Armstrong

Gabriel / Trickster

Richard Speight Jr.

Charlie Bradbury

Felicia Day

John Winchester

Jeffrey Dean Morgan

Lisa Braeden

Cindy Sampson

Billie

Lisa Berry

Eli / Benny Lafitte

Ty Olsson

Kevin Tran

Osric Chau

Naomi

Amanda Tapping

Kelly Kline

Courtney Ford

Ellen Harvelle

Samantha Ferris

Donatello Redfield / God

Keith Szarabajka

Hannah / Caroline Johnson / Young Mother

Erica Carroll

Jo Harvelle

Alona Tal

Duma / The Shadow / Robin

Erica Cerra

Liane Balaban

Meg Masters

Rachel Miner

Abaddon

Alaina Huffman

Eileen Leahy

Shoshannah Stern

Maggie

Katherine Evans

Donna Hanscum

Briana Buckmaster

Balthazar

Sebastian Roché

Claire Novak

Kathryn Newton

Young Sam Winchester

Colin Ford

Rufus Turner

Steven Williams

Garth Fitzgerald / Garth Fitzgerald

DJ Qualls

Toni Bevell

Elizabeth Blackmore

Bela Talbot

Lauren Cohan

Ruby

Katie Cassidy

Jessica Moore

Adrianne Palicki

Death

Julian Richings

Edgar

Benito Martinez

Ben Braeden

Nicholas Elia

Gadreel / Ezekiel

Tahmoh Penikett

Mick Davies

Adam Fergus

Sister Jo / Anael

Danneel Ackles

Michael

Christian Keyes

Asmodeus

Jeffrey Vincent Parise

Alex Jones

Katherine Ramdeen

Kaia Nieves / Dark Kaia

Yadira Guevara-Prip

Ash

Chad Lindberg