Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Agnes Skinner (voice) / Dolph (voice) / (voice)

Tress MacNeille

Reverend Jim Ignatowski

Christopher Lloyd

Himself

Johnny Mathis

CGI Homer Simpson

John Ratzenberger

Philip J. Fry / Prof. Hubert J. Farnsworth / Dr. Zoidberg

Billy West

Captain Bowditch

Nick Offerman

Annika Van Houten

Carice van Houten

King Toot

Will Forte

Mr. Lassen

Willem Dafoe

Elon Musk

Elon Musk

Princess Kemi

Yaya DaCosta

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Herself

Cat Deeley

Himself

Pharrell Williams

Maxine Lombard

Jane Fonda

Doug Blattner

Nathan Fielder

Sideshow Bob (voice)

Kelsey Grammer

Alf Clausen

Felix

David Hyde Pierce

Judge Henry X. Harper in Miracle on 34th Street (archive footage)

Gene Lockhart

Turanga Leela

Katey Sagal

Jacques (voice) / Hank Scorpio (voice) / Tab Spangler

Albert Brooks

Himself

Richard Branson

Mona Simpson (voice)

Glenn Close

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Young Man

Rich Sommer

Himself

Robert Siegel

Sammy Hagar

Sammy Hagar

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Herself

Sarah Silverman

Bender

John DiMaggio

James L. Brooks

Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Dr. Hibbert (voice) / Narrator (voice) / Jay G (voice)

Kevin Michael Richardson

Rick Sanchez / Morty Smith

Justin Roiland

Colonel Leslie Hapablap

R. Lee Ermey

Apu's singing voice

Aron Michael Manderosian

Himself

Jeff Ross

Narrator

Marc Wilmore

Llewellyn Sinclair (voice) / Artie Ziff (voice) / Enrico Irritazio (voice)

Jon Lovitz

Al Jean

Apu's singing voice

Robert J. Manderosian

Mike B. Anderson*

Additional Voices (voice) / (voice) / Prisoners

Karl Wiedergott*

Additional Voices

David Silverman

Hyman Krustofsky (voice)

Jackie Mason

Hermes Conrad

Phil LaMarr

Apu's singing voice / Nick Delacourt

Matthew Sweet

John Frink

Amy Wong

Lauren Tom

Future Bart / Future Lisa / Future Marge / Future Creatures

Don Hertzfeldt

Tom Gammill

Rodney Dangerfield / Clive Meriwether / Neil Simon

Maurice LaMarche

Scruffy

David Herman

Monkeys / Princess (voice) / Executive Vice-President (voice)

Frank Welker

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Matt Groening

Bonita Pietila

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Max Pross

Richard Raynis

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Mike Reiss

Bernice Hibbert (voice) / (voice) / Cannabis Influencer (voice)

Dawnn Lewis

Richard Sakai

Mike Scully

Matt Selman

Sam Simon

Denise Sirkot

Kumiko Albertson (voice) / Truth-Anne (voice) / Band Student (voice)

Jenny Yokobori

Norbert Gastell

Anke Engelke

Helen Lovejoy (voice) / Maude Flanders (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Sandra Schwittau

Julio Franco (voice) / Julio (voice) / Audience

Tony Rodriguez

Sabine Bohlmann

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Lewis Clark (voice) / Janine Powell (voice) / Kindergartener (voice)

Kimberly Brooks

Lunchlady Doris (voice) / Ice cream lady (voice) / Della (voice)

Doris Grau

Susan / Collette the Waitress (voice) / Weasel #2

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Rayshelle Peyton (voice)

Kerry Washington

Backstage Mom (voice) / Mrs. Butterworth (voice) / Old Lady (voice)

Valerie Harper

Murphy (voice) / Dana Gould (voice) / I.N.S. Agent (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Clayton (voice)

Michael York

Bumblebee Man (voice) / Lisa's Student (voice) / Gambling Old Man (voice)

Eric Lopez

Stephen Hawking (voice)

Stephen Hawking

Sarah Wiggum (voice)

Megan Mullally

Akira Kurosawa (voice) / Wink - The Game Show Host (voice) / Waiter (voice)

George Takei

J. Jonah Jameson (voice) / Victor Kleskow (voice) / Tabloid Editor (voice)

J.K. Simmons