Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Agnes Skinner (voice) / Dolph (voice) / (voice)

Tress MacNeille

Ben

Seth MacFarlane

Reverend Elijah Hooper

Edward Norton

T-Rex

Patton Oswalt

Ms. Cantwell

Tina Fey

School Therapist

Wanda Sykes

Rita LaFleur

Anika Noni Rose

Severus Snape / Prime Minister

Benedict Cumberbatch

Dan Gillick

Steve Carell

Llewellyn Sinclair (voice) / Artie Ziff (voice) / Enrico Irritazio (voice)

Jon Lovitz

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Herb Powell

Danny DeVito

Slava

Bill Hader

Ramona

Lisa Lampanelli

Himself

Sonny Rollins

Lloyd

Tom Waits

Backstage Mom (voice) / Mrs. Butterworth (voice) / Old Lady (voice)

Valerie Harper

Sideshow Bob (voice)

Kelsey Grammer

Herself

Janet Reno

Himself

Jeff Gordon

Capital City Singer

Tony Bennett

Orson Welles (voice) / (voice) / Chef Naziwa

Maurice LaMarche

Mary Spuckler

Zooey Deschanel

Akira Kurosawa (voice) / Wink - The Game Show Host (voice) / Waiter (voice)

George Takei

Portia

Rashida Jones

Terrence

Fred Armisen

Herself

Jennifer Tilly

Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Dr. Hibbert (voice) / Narrator (voice) / Jay G (voice)

Kevin Michael Richardson

Himself

Richard Dawkins

Himself

Al Roker

Zhenya

Jane Krakowski

Janet Reno

Maggy Reno-Hurchalla

Norbert Gastell

Walter White

Bryan Cranston

Himself

Alex Trebek

Himself

Max Weinberg

Emily

Carrie Brownstein

Himself

Don Pardo

Vigorous Older Man

Patrick Stewart

Himself

Marvin Hamlisch

Bleedin' Gums Murphy (Archive)

Ron Taylor

Jesse Pinkman

Aaron Paul

Himself

Ken Burns

Anke Engelke

Himself

Justin Bieber

Himself

Robert A. Caro

Man Baby

Terry W. Greene

Additional Voices (voice) / (voice) / Prisoners

Karl Wiedergott*

Sandra Schwittau

Darcy

Natalie Portman

Himself

Colin Meloy

'Easter Parade' Vocals

Michael Dees

Jenny

Anne Hathaway

Gina Vendetti

Sarah Michelle Gellar

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Nikki McKenna

Sarah Silverman

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Bernice Hibbert (voice) / (voice) / Cannabis Influencer (voice)

Dawnn Lewis

Mona Simpson (voice)

Glenn Close

Kumiko Albertson (voice) / Truth-Anne (voice) / Band Student (voice)

Jenny Yokobori

Hyman Krustofsky (voice)

Jackie Mason

Helen Lovejoy (voice) / Maude Flanders (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Jacques (voice) / Hank Scorpio (voice) / Tab Spangler

Albert Brooks

Julio Franco (voice) / Julio (voice) / Audience

Tony Rodriguez

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Lewis Clark (voice) / Janine Powell (voice) / Kindergartener (voice)

Kimberly Brooks

Lunchlady Doris (voice) / Ice cream lady (voice) / Della (voice)

Doris Grau

Susan / Collette the Waitress (voice) / Weasel #2

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Rayshelle Peyton (voice)

Kerry Washington

Monkeys / Princess (voice) / Executive Vice-President (voice)

Frank Welker

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Murphy (voice) / Dana Gould (voice) / I.N.S. Agent (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Clayton (voice)

Michael York

Bumblebee Man (voice) / Lisa's Student (voice) / Gambling Old Man (voice)

Eric Lopez

Stephen Hawking (voice)

Stephen Hawking

Sarah Wiggum (voice)

Megan Mullally

J. Jonah Jameson (voice) / Victor Kleskow (voice) / Tabloid Editor (voice)

J.K. Simmons