Gregorio Cortez

Antonio Banderas

Carmen Cortez

Alexa PenaVega

Ingrid Cortez

Carla Gugino

Juni Cortez

Daryl Sabara

Fegan Floop

Alan Cumming

Alexander Minion

Tony Shalhoub

Mrs. Gradenko

Teri Hatcher

Felix Gumm

Cheech Marin

Financier

Dick Clark

Mr. Lisp

Robert Patrick

Devlin

George Clooney

Isidor 'Machete' Cortez

Danny Trejo

Tom Savini

Donnagon/Donnamight

Mike Judge

Cool Spy

Richard Linklater

Pastor

Guillermo Navarro

Agent Johnny

Johnny Reno

FoOglie No. 1/Flower

Shannon Shea

Carmen's Friend

Kara Slack

FoOglie No. 3/Too Too

Trant Batey

FoOglie No. 2/Tall & Skinny

Norman Cabrera

Brat

Andy W. Bossley

Brat's Dad

Jeff Dashnaw

Brat's Dad

Jeffrey J. Dashnaw

"Intruder" Spy Kid

Evan Sabba

Cab Driver

Ehrmahn Ospina

Cab Driver

Ermahn Ospina

Excited Kid at Playground

Emilio Navarro Mackissack

Intruder Spy Kid

Evan Sabara

President's Robot Daughter

Rachel Duhame

Lisp's Robot Son

Houston Hooker

Financier

Louis Black

Financier

Charles Ramirez-Berg

Financier

Steve Havens

Financier

Roberto Santibanez

Spy Driver

Julio Villareal

Spy Bridesmaid

Becca Rodriguez

Spy Bridesmaid

Patricia Vonne

Newscaster

Angela Lanza

Baby Carmen

Addisyn Fair

Mary Vernieu

Anne McCarthy*