Hank Hill / Boomhauer (voice)
Mike Judge
Peggy Hill (voice)
Kathy Najimy
Bobby Hill
Pamela Segall
Dale Gribble (voice)
Johnny Hardwick
Luanne Platter (voice)
Brittany Murphy
Bill Dauterive / Buck Strickland (voice)
Stephen Root
Reverend Karen Stroup
Mary Tyler Moore
Coach Lucas
Will Ferrell
Julie/Rita Bevacqua
Gabrielle Carteris
Fire Chief
Barry Corbin
Minh Souphanousinphone/Kahn 'Connie' Souphanousinphone Jr.
Lauren Tom
Rad Thibodeaux
Matthew McConaughey
Dr. Rubin
William H. Macy
Mexican Judge
Erik Estrada
Boyce Hubert
Billy Bob Thornton
Chuck Mangione (voice)
Chuck Mangione
Heck Dorland
Earl Bullock
Mrs. Tobbis
Janet Waldo
Kate
Jane Wiedlin
Nancy Hicks-Gribble / Didi Hill (voice)
Ashley Gardner
Lane Pratley
Dwight Yoakam
Helen Pell
Mary Kay Place
Lillian
Phyllis Diller
Marie
Sarah Michelle Gellar
Instructor
John Ashton
Clerk (voice) / Mr. Holloway (voice) / Sergeant Barber (voice)
Billy West
Delia
Betty White
A.J.
Norm Hiscock
(voice) / Jimmy Witchard (voice) / Eustis Miller (voice)
David Herman
Ally
Julie Hagerty
Kahn Souphanousinphone / Cotton Hill (voice)
Toby Huss
Chet Elderson
Buddy Ebsen
Marci
Carol Alt
Deejay
Pauly Shore
Maddy Platter (voice) / Marie's Mother (voice) / Nurse (voice)
Joanna Gleason
Sylvia
Kathy Ireland
Director
Nick Jamison
Wendy
Stephanie Hodge
Miss Kremzer
Jennifer Coolidge
Sharona Johnson
Dawnn Lewis
Guest Voice
Steven Banks
Dr. Bhudamanjur
Iqbal Theba
John Redcorn (voice) / John Redcorn / Driver #2 (voice)
Jonathan Joss
Maureen
Uta Hagen
(voice) / Burl Arlington / Harv Judd
Phil Hendrie
Cashier
Louise Jaffe
Tilly Hill (voice) / Nurse (voice) / (voice)
Beth Grant
Kimmi
Tara Charendoff
Guest Voice
Lisa Jane Persky
Daniel
Dan Butler
Enrique (voice) / (voice)
Eloy Casados
Principal Moss (voice) / Principal Moss / William B. Travis (voice)
Dennis Burkley
Chad
Phil Buckman
Guest Voice
J. Evan Bonifant
Maria Montalvo
Bertila Damas
Waiter/Frat Guy
Dave Buzzotta
Randy Miller (voice) / (voice) / Velma Throckmorton (voice)
Cheryl Holliday
Curator/Sheriff
Wally Wingert
Kahn's Boss
Glenn Lucas
Guest Voice
Jim Cummings
(voice) / Mikey / Randy
Scott Klace
Firefighter
Alan Freedland
Guest Voice
Andrew Dorsett
Emily
Jill Parker
Guest Voice
Rich Rinaldi
Lane Pratley (voice) / (voice) / Jimsey (voice)
Dave Thomas
Tilly's Friend
Dena Dietrich
(voice) / Fire Chief / Reverend Thomason (voice)
Maurice LaMarche
Lucky (voice) / Lucky / Mud Dobber (voice)
Tom Petty
(voice) / Roger 'Booda' Sack (voice) / Ramsey (voice)
Phil LaMarr
Enrique (voice) / Enrique / Octavio (voice)
Danny Trejo
(voice) / Nguc Phong (voice) / Doctor (voice)
James Sie
(voice) / Kahn's Boss (voice) / Football Kid (voice)
Glenn L. Lucas
Customer (voice) / Redneck (voice) / (voice)
Randal Reeder
Bob Jenkins (voice) / Bob Jenkins / Travis (voice)
Henry Gibson
Officer Brown (voice) / Ranger Bradley / Reclining Hippie (voice)
Fred Willard
Emily (voice) / (voice) / Emily
Ashley Johnson
Michiko (voice) / Mrs. Kalaiki-Alii (voice) / Mrs. Laoma Souphanousinphone (voice)
Amy Hill
Chris Sizemore (voice) / Ed Burnett (voice) / Rob Holguin (voice)
Chris Elliott
(voice) / Joseph Gribble / Mr. Haggerty (voice)
Breckin Meyer
Kenny (voice) / Caleb (voice) / Arrow Kid #2
Paul Butcher
(voice) / Pops (voice) / C. Everett Koop (voice)
Jim Cummings
Jane (voice) / Waitress (voice) / Dawn (voice)
Rini Bell
(voice) / Guard (voice) / Cameraman
Wyatt Cenac