Hank Hill / Boomhauer (voice)

Mike Judge

Peggy Hill (voice)

Kathy Najimy

Bobby Hill

Pamela Segall

Dale Gribble (voice)

Johnny Hardwick

Luanne Platter

Brittany Murphy

Bill Dauterive/Buck Strickland

Stephen Root

Reverend Karen Stroup

Mary Tyler Moore

Coach Lucas

Will Ferrell

Julie/Rita Bevacqua

Gabrielle Carteris

Fire Chief

Barry Corbin

Minh Souphanousinphone/Kahn 'Connie' Souphanousinphone Jr.

Lauren Tom

Rad Thibodeaux

Matthew McConaughey

Dr. Rubin

William H. Macy

Mexican Judge

Erik Estrada

Boyce Hubert

Billy Bob Thornton

Chuck Mangione (voice)

Chuck Mangione

Heck Dorland

Earl Bullock

Mrs. Tobbis

Janet Waldo

Kate

Jane Wiedlin

Nancy Hicks Gribble (voice)

Ashley Gardner

Lane Pratley

Dwight Yoakam

Helen Pell

Mary Kay Place

Lillian

Phyllis Diller

Marie

Sarah Michelle Gellar

Dale Gribble / Cotton Hill / Kahn Souphanousinphone (voice)

Toby Huss

Instructor

John Ashton

Mr. Holloway (voice) / Clerk (voice) / Sergeant Barber (voice)

Billy West

Delia

Betty White

A.J.

Norm Hiscock

(voice) / Buckley (voice) / Jimmy Witchard (voice)

David Herman

Ally

Julie Hagerty

Chet Elderson

Buddy Ebsen

Marci

Carol Alt

Deejay

Pauly Shore

Maddy Platter (voice) / Marie's Mother (voice) / Nurse (voice)

Joanna Gleason

Sylvia

Kathy Ireland

Director

Nick Jamison

Wendy

Stephanie Hodge

Miss Kremzer

Jennifer Coolidge

Sharona Johnson

Dawnn Lewis

Guest Voice

Steven Banks

Dr. Bhudamanjur

Iqbal Theba

John Redcorn (voice) / John Redcorn / Driver #2 (voice)

Jonathan Joss

Maureen

Uta Hagen

(voice) / Burl Arlington / Harv Judd

Phil Hendrie

Cashier

Louise Jaffe

Nurse (voice) / Tilly Hill (voice) / (voice)

Beth Grant

Kimmi

Tara Charendoff

Guest Voice

Lisa Jane Persky

Daniel

Dan Butler

Enrique (voice) / (voice)

Eloy Casados

Joseph Gribble (voice) / (voice) / Joseph Gribble

Breckin Meyer

Principal Moss (voice) / (voice) / Principal Moss

Dennis Burkley

Chad

Phil Buckman

Guest Voice

J. Evan Bonifant

Maria Montalvo

Bertila Damas

Waiter/Frat Guy

Dave Buzzotta

Randy Miller (voice) / (voice) / Velma Throckmorton (voice)

Cheryl Holliday

Curator/Sheriff

Wally Wingert

Kahn's Boss

Glenn Lucas

Pops (voice) / Bounty Hunter / Jimmy Helstrom (voice)

Jim Cummings

Firefighter

Alan Freedland

Guest Voice

Andrew Dorsett

Emily

Jill Parker

Guest Voice

Rich Rinaldi

Lane Pratley (voice) / (voice) / Toothless Loser (voice)

Dave Thomas

Tilly's Friend

Dena Dietrich

(voice) / Professor John Lerner (voice) / Fire Chief

Maurice LaMarche

(voice) / Mikey / Randy

Scott Klace

Lucky (voice) / Lucky / Mud Dobber (voice)

Tom Petty

(voice) / Roger 'Booda' Sack (voice) / Vietnam War Veteran (voice)

Phil LaMarr

Enrique (voice) / (voice) / Lifeguard

Danny Trejo

(voice) / Nguc Phong (voice) / Doctor (voice)

James Sie

Kahn Souphanousinphone

Ronny Chieng

(voice) / Kahn's Boss (voice) / Football Kid (voice)

Glenn L. Lucas

Customer (voice) / Rollo / Coach (voice)

Randal Reeder

Bob Jenkins (voice) / Bob Jenkins / Travis (voice)

Henry Gibson

Officer Brown (voice) / Ranger Bradley / Reclining Hippie (voice)

Fred Willard

Emily (voice) / (voice) / Emily

Ashley Johnson

Mrs. Kalaiki-Alii (voice) / Michiko (voice) / Mrs. Laoma Souphanousinphone (voice)

Amy Hill

Chris Sizemore (voice) / Rob Holguin (voice) / Ed Burnett (voice)

Chris Elliott

Kenny (voice) / Caleb (voice) / Arrow Kid #2

Paul Butcher

Jane (voice) / Olivia (voice) / Dawn (voice)

Rini Bell

(voice) / Cameraman / Dr. Stephens (voice)

Wyatt Cenac