Doc Sportello

Joaquin Phoenix

Lt. Det. Christian F. "Bigfoot" Bjornsen

Josh Brolin

Coy Harlingen

Owen Wilson

Shasta Ray Hepworth

Katherine Waterston

Deputy D.A. Penny Kimball

Reese Witherspoon

Sauncho Smilax

Benicio del Toro

Dr. Rudy Blatnoyd

Martin Short

Hope Harlingen

Jena Malone

Petunia Leeway

Maya Rudolph

Michael Z. Wolfmann

Eric Roberts

Sortilege

Joanna Newsom

Denis

Jordan Christian Hearn

Japonica

Sasha Pieterse

Jade

Hong Chau

Aunt Reet

Jeannie Berlin

Ensenada Slim

Taylor Bonin

Tariq Khalil

Michael Kenneth Williams

Sloane Wolfmann

Serena Scott Thomas

Dr. Buddy Tubeside

Martin D. Dew

Crocker Fenway

Martin Donovan

Bambi

Shannon Collis

Glenn Charlock

Christopher Allen Nelson

Agent Flatweed

Sam Jaeger

News Reporter

Catherine Haena Kim

Agent Borderline

Timothy Simons

Amethyst Harlingen

Vivienne Khaledi

Chlorinda

Jillian Bell

Luz

Yvette Yates

Riggs Warbling

Andrew Simpson

Dr. Buddy Tubeside

Martin Dew

Cop With Bigfoot

Joe Dioletto

Luz

Yvette Yates Redick

Burke Stodger

Jack Kelly

Smedley

Christian Williams

The Boards

The Growlers

Clancy Charlock

Michelle Sinclair

Clancy Charlock

Belladonna

Howdy Doper's Phone Voice (voice)

Alina Gatti

Xandra

Elaine Tan

LAPD Officer #1

Wilson Bethel

LAPD Officer #2

Anders Holm

Bigfoot's Kid

Emmet Unverzagt

Japanese Cook

Osamu Saito

Dr. Lily Hammer

Erica Sullivan

Dr. Threeply's Assistant #1

Eva Fisher

Dr. Threeply

Jefferson Mays

Dr. Threeply's Assistant #2

Jackie Michele Johnson

Kimberly

Katie Schwartz

Dr. Igor

Charley Morgan

Portola Barkeep

Steven Wiig

Golden Fang Daughter

Madison Leisle

Puck Beaverton

Keith Jardine

Mrs. Chastity Bjornsen

Delaina Mitchell

FBI Agent

Eric Womack

Rhus Frothingham

Michael Cotter

Beach Girl

Marianne Bourg

Adrian Prussia

Peter McRobbie

Adrian Prussia's Secretary

Shannon C. Sullivan

Lourdes

Diana Elizabeth Torres

Golden Fang Mother

Samantha Lemole

Mr. Robinson

Christopher Karl Johnson

Patient

Chelsea O'Toole

Golden Fang Son

Liam Van Joosten

Commando

Will C.

Golden Fang Father

Matt Doyle

Jordan David

Buddhist Monk

David Prak

Bodhi

Amy Ferguson

Zinnia

Emma Dumont