Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Norbert Gastell

Himself

Michael Moore

Milhouse Van Houten

Pamela Hayden

Hyman Krustofsky (voice)

Jackie Mason

Themselves

Brave Combo

Henry

Simon Cowell

Professor John Frink, Sr.

Jerry Lewis

Mona Simpson (voice)

Glenn Close

Artie Ziff / Jay Sherman / Professor Lombardo / Aristotle Amadopoulis / Llewellyn Sinclair

Jon Lovitz

Gina Vendetti

Sarah Michelle Gellar

Herself

Ashley Olsen

Salem Saberhagen

Nick Bakay

Himself

Tony Blair

Matt Groening

Matt Groening

Elisabeth Volkmann

Herself

Nichelle Nichols

Herself

J.K. Rowling

Mr. T

Mr. T

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Herself

Mary-Kate Olsen

Herself

Jennifer Garner

K.I.T.T.

William Daniels

Agnes Skinner (voice) / (voice) / Dolph (voice)

Tress MacNeille

Herself

Isabel Sanford

Himself

Dudley Herschbach

Himself

Tom Clancy

Sandra Schwittau

Himself

Ian McKellen

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott*

Soulful Prune

James Gilstrap

Joe Millionaire

Evan Marriott

Rambler-Crane Series Robot

Dick Tufeld

Himself

Oscar De La Hoya

Sabine Bohlmann

Himself

Thomas Pynchon

Warden

Charles Napier

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Edwina

Jane Leeves

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Sideshow Bob (voice)

Kelsey Grammer

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Rayshelle Peyton (voice)

Kerry Washington

Milhouse Van Houten (voice)

Kelly Macleod

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Baboons (voice) / Santa's Little Helper / Mr. Teeny

Frank Welker

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow