Hank Hill

Mike Judge

Peggy Hill

Kathy Najimy

Bobby/Clark Peters

Pamela Segall Adlon

Dale Gribble (voice)

Johnny Hardwick

Luanne Platter

Brittany Murphy

Bill Dauterive / Buck Strickland (voice)

Stephen Root

John Redcorn (voice) / John Redcorn / Driver #2 (voice)

Jonathan Joss

Eugene Grandy

John Ritter

David Kalaiki-Alii

Brendan Fraser

Garry Kasner

Carl Reiner

Councilman Fred Ebberd

Chelcie Ross

Dr. Newman/Dave

Tom McGowan

Nancy Hicks-Gribble / Didi Hill (voice)

Ashley Gardner

Keegan Evans

Ryan Janis

Tammy Duvall

Renée Zellweger

Digby Wilkins

James Brown

(voice) / Jimmy Witchard (voice) / Eustis Miller (voice)

David Herman

Guest Voice

Ann Richards

Amy Pittman

Lisa Kudrow

Guest Voice

Gwen Stefani

Kahn Souphanousinphone / Cotton Hill (voice)

Toby Huss

Mr. Popper

Tom Poston

Guest Voice

Castulo Guerra

Lenore

Ellen Barkin

(voice) / Burl Arlington / Harv Judd

Phil Hendrie

Minh Souphanousinphone / Connie Souphanousinphone (voice)

Lauren Tom

Dr. Benson/Burt Halverstrom

Stephen Tobolowsky

Guest Voice

Tom Dumont

Dr. Tate/Larry

Harry Groener

Mr. McKay

Paul Giamatti

Alabaster Jones

Snoop "Doggy" Dogg

Terrell Cartwright

Howie Long

(voice) / Joseph Gribble / Mr. Haggerty (voice)

Breckin Meyer

Tilly Hill (voice) / Nurse (voice) / (voice)

Beth Grant

Marty Mendez

Marcelo Tubert

Stinky

Edward Asner

Preston Rogers

Terry Bradshaw

Guest Voice

Adrian Young

Rhett Van Der Graaf

Owen Wilson

Lane Pratley (voice) / (voice) / Jimsey (voice)

Dave Thomas

Cockroach

Jim Dauterive

Guest Voice

Tony Kanal

Irwin Linker

Jack Carter

Reynolds Penland

Robert Stack

Guest Voice

Dave Buzzotta

Emily

Jill Parker

Principal Moss (voice) / Principal Moss / William B. Travis (voice)

Dennis Burkley

(voice) / Mikey / Randy

Scott Klace

Lucky (voice) / Lucky / Mud Dobber (voice)

Tom Petty

(voice) / Roger 'Booda' Sack (voice) / Ramsey (voice)

Phil LaMarr

Enrique (voice) / Enrique / Octavio (voice)

Danny Trejo

(voice) / Nguc Phong (voice) / Doctor (voice)

James Sie

(voice) / Kahn's Boss (voice) / Football Kid (voice)

Glenn L. Lucas

Chuck Mangione (voice)

Chuck Mangione

Customer (voice) / Redneck (voice) / (voice)

Randal Reeder

Maddy Platter (voice) / Marie's Mother (voice) / Nurse (voice)

Joanna Gleason

(voice) / Fire Chief / Reverend Thomason (voice)

Maurice LaMarche

Bob Jenkins (voice) / Bob Jenkins / Travis (voice)

Henry Gibson

Officer Brown (voice) / Ranger Bradley / Reclining Hippie (voice)

Fred Willard

James (voice) / Eric (voice) / Kimmi (voice)

Tara Strong

Emily (voice) / (voice) / Emily

Ashley Johnson

Clerk (voice) / Mr. Holloway (voice) / Sergeant Barber (voice)

Billy West

Michiko (voice) / Mrs. Kalaiki-Alii (voice) / Mrs. Laoma Souphanousinphone (voice)

Amy Hill

Chris Sizemore (voice) / Ed Burnett (voice) / Rob Holguin (voice)

Chris Elliott

Kenny (voice) / Caleb (voice) / Arrow Kid #2

Paul Butcher

Randy Miller (voice) / (voice) / Velma Throckmorton (voice)

Cheryl Holliday

Enrique (voice) / (voice)

Eloy Casados

(voice) / Pops (voice) / C. Everett Koop (voice)

Jim Cummings

Jane (voice) / Waitress (voice) / Dawn (voice)

Rini Bell

(voice) / Guard (voice) / Cameraman

Wyatt Cenac

Director

Shaun Cashman

Director

Klay Hall

Director

Allan Jacobsen

Director

Dominic Polcino

Director

Matt Engstrom