Dr Otto Octavius / Doc Ock

Alfred Molina

Peter Parker / Spider-Man

Tobey Maguire

Harry Osborn

James Franco

Mary Jane Watson

Kirsten Dunst

May Parker

Rosemary Harris

J. Jonah Jameson

J.K. Simmons

Rosie Octavius

Donna Murphy

John Jameson

Daniel Gillies

Dr. Curt Connors

Dylan Baker

Joseph "Robbie" Robertson

Bill Nunn

Louise

Vanessa Ferlito

Mr. Aziz

Aasif Mandvi

Norman Osborn/Green Goblin

Willem Dafoe

Ben Parker

Cliff Robertson

Hoffman

Ted Raimi

Miss Brant

Elizabeth Banks

Dr. Davis

Gregg Edelman

Snooty Usher

Bruce Campbell

Mr. Ditkovitch

Elya Baskin

Ursula

Mageina Tovah

Man at Fire

Michael Edward Thomas

Raymond

Daniel Dae Kim

Elevator Passenger

Hal Sparks

Mr. Jacks

Joel McHale

Man Dodging Debris

Stan Lee

Dr. Isaacs

Kelly Connell

Garbage Man

Brent Briscoe

Receptionist

Emily Deschanel

Henry Jackson

Jason Fiore-Ortiz

Man on Balcony

Scott Spiegel

OsCorp Executive

Andy Bale

Mrs. Jameson

Christine Estabrook

Society Woman

Molly Cheek

Woman at Web

Joy Bryant

Houseman

John Paxton

Skeptical Scientist

Joanne Baron

OsCorp Representative

Peter McRobbie

Injured Scientist

Tim Jerome

Mrs. Watson

Taylor Gilbert

Stage Manager

Peter Vouras

Pizza "Heist" Witness

Donnell Rawlings

Boy saved by Spider-Man

Zachry Rogers

Girl saved by Spider-Man

Ella Rogers

Poker Player

Louis Lombardi

Amazed Kid

Marc John Jefferies

Amazed Kid

Roshon Fegan

Theater Traffic Cop

Brendan Patrick Connor

'Algernon'

Reed Diamond

'Jack'

Dan Callahan

Violinist

Elyse Dinh

Doctor

John Landis

Chainsaw Doctor

Tim Storms

Clawing Nurse

Susie Park

Screaming Nurse

Tricia Peters

Screaming Nurse

Patricia M. Peters

Woman at Fire

Anne Betancourt

Child in Burning Building

Venus Lam

Fireman

Bill E. Rogers

Fireman

Joe Virzi

Boy with Mask

Jopaul Epp

Train Conductor

Tom Carey

Boy with Mask

Jopaul Van Epp

Train Passenger

Peter Allas

Boy with Mask

Weston Epp

Train Passenger

Bill Calvert

Train Passenger

Brianna Brown

Train Passenger

Tony Campisi

Train Passenger

Joey Diaz

Train Passenger

Chloe Dykstra

Train Passenger

Simone Gordon

Train Passenger

Dan Hicks

Train Passenger

Julia Max

Train Passenger

Savannah Pope

Train Passenger

Timothy Patrick Quill

Train Passenger

Jill Sayre

Train Passenger

Rickey G. Williams

NYPD Officer

Mike Arthur

Pizza Man (uncredited)

Frank Bonsangue

NYPD Officer (uncredited)

Michael Arthur

Chinese Daughter (uncredited)

Cindy Cheung

Train Passenger (uncredited)

Phil LaMarr

Fireman 2 (uncredited)

Andre M. Johnson

Piano Player in Planetarium (uncredited)

Peter Cincotti

Little Girl Playing on Steps

Peyton List

Blue Collar Guy (uncredited)

Troy Metcalf

Little Boy Playing on Steps

Spencer List

Pedestrian (uncredited)

Scott Ross

Screaming Woman (uncredited)

Bonnie Somerville

Columbia University Student (uncredited)

Wesley Volcy

Man at Web (uncredited)

Lou Volpe

Bearded Doctor (uncredited)

Garrett Warren

Priest at Mary Jane's Wedding (uncredited)

Joseph M. Caracciolo

Pedestrian (uncredited)

David Boston

Passenger (uncredited)

Sho Brown

Parent (uncredited)

Sal Ardisi

Planetarium (uncredited)

Edward Johnson

Hot Dog Vendor (uncredited)

Grant Curtis

Victim (uncredited)

Vince Cupone

Stock Broker (uncredited)

William E. Corcoran

Victim

Vinny Capone