Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Milhouse Van Houten

Pamela Hayden

Agnes Skinner (voice) / Dolph (voice) / (voice)

Tress MacNeille

Diggs

Daniel Radcliffe

Sideshow Bob (voice)

Kelsey Grammer

Himself

Will Lyman

Gretchen

Elisabeth Moss

Klaus Ziegler

Max von Sydow

Jenda

Amy Poehler

Himself

Stan Lee

Lucas Bortner

Zach Galifianakis

Isabel Gutiérrez

Eva Longoria

Agent Annie Crawford

Kristen Wiig

Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Mona Simpson (voice)

Glenn Close

Llewellyn Sinclair (voice) / Enrico Irritazio (voice) / Artie Ziff (voice)

Jon Lovitz

Dr. Hibbert (voice) / Narrator (voice) / Security Guard (voice)

Kevin Michael Richardson

Herself

Rachel Maddow

Himself

Peter Sagal

Himself

Judd Apatow

Himself/ Mafia

Andrés Cantor

Himself

Anderson Cooper

Waitress

Renee Ridgeley

Maude Flanders (voice) / Helen Lovejoy (voice) / Luann Van Houten (voice)

Maggie Roswell

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Himself

Harlan Ellison

Jenny

Tavi Gevinson

Herself

Leslie Mann

Himself

Joe Namath

Himself

Carl Kasell

Himself

Edwin Moses

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Paul Rudd / Judd Apatow

Paul Rudd

Booth Wilkes-John

John Oliver

Himself

Seth Rogen

Additional Voices

Joey Vieira

Additional Voices (voice) / (voice) / Garbage Man (voice)

Karl Wiedergott*

Himself

Channing Tatum

Norbert Gastell

Himself

Rob Halford

Deputy Director Gratman

Will Arnett

Anke Engelke

Sandra Schwittau

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Bernice Hibbert (voice) / (voice) / Bernice Hibbert

Dawnn Lewis

Hyman Krustofsky (voice)

Jackie Mason

Kumiko Albertson (voice) / Truth-Anne (voice) / Band Student (voice)

Jenny Yokobori

Helen Lovejoy (voice) / Maude Flanders (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Jacques (voice) / Hank Scorpio (voice) / Brad Goodman (voice)

Albert Brooks

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Janine Powell (voice) / Lewis Clark (voice) / Kindergartener (voice)

Kimberly Brooks

Lunchlady Doris (voice) / Ice cream lady (voice) / Lunchlady (voice)

Doris Grau

Minnesota Girl / Maria Dominguez / Paper Boy (voice)

Jo Ann Harris

Julio (voice) / Julio Franco (voice) / Audience

Tony Rodriguez

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Rayshelle Peyton (voice)

Kerry Washington

Ms. Myles (voice) / Old Lady (voice) / Mrs. Butterworth (voice)

Valerie Harper

Tough Street Dog / Mean Zoo Animals (voice) / Lord Nibbler (voice)

Frank Welker

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Murphy (voice) / Dana Gould (voice) / I.N.S. Agent (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Clayton (voice) / Mason Fairbanks (voice)

Michael York

Bumblebee Man (voice) / Lisa's Student (voice) / Gambling Old Man (voice)

Eric Lopez

Stephen Hawking (voice)

Stephen Hawking

Sarah Wiggum (voice)

Megan Mullally

Wink - The Game Show Host (voice) / George Takei (voice) / Akira Kurosawa (voice)

George Takei

Victor Kleskow (voice) / Dr. Jessup (voice) / Tabloid Editor (voice)

J.K. Simmons

Director

Mike B. Anderson*

Director

Mark Kirkland

Director

Neil Affleck

Director

Chuck Sheetz

Director

David Silverman

Director

Lauren MacMullan

Director

Dominic Polcino

Director

Swinton O. Scott III

Director

Rich Moore

Director

Raymond S. Persi

Director

Pete Michels

Director

Jennifer Moeller

Director

Mike B. Anderson

Director

Michael Polcino