Stan Smith / Roger (voice)
Seth MacFarlane
Hayley Smith (voice)
Rachael MacFarlane
Francine Smith
Wendy Schaal
Steve Smith (voice)
Scott Grimes
Klaus
Dee Bradley Baker
Tony Perotti
Geoffrey Arend
Drake
Jeffrey Anderson-Gunter
Buckle (voice) / (voice) / Santa Claus (voice)
Matt McKenna
Avery Bullock (voice) / Avery Bullock as B (voice) / Jeff Fischer (voice)
Patrick Stewart
Huell Howser (voice) / Wolf Poacher (voice) / Lorne Mikeys (voice)
James Adomian
Janet
Jillian Bell
Preacher (voice) / (voice) / Chicago Dave (voice)
Jon Daly
Nut Butter
Jordan Blum
Camper
Ava Acres
Snot Lonstein (voice) / Snot Lonstein / Eli Weisel (voice)
Curtis Armstrong
(voice) / Michelle (voice) / Woman (voice)
Paget Brewster
Meredith
Sarah Chalke
Stewardess
Cherry Chevapravatdumrong
(voice) / Successful Classmate (voice) / Dawson Family Member (voice)
Brian Boyle
Employee
Abraham Benrubi
Johnny Concussion
Diedrich Bader
Jack Smith (voice) / Trailer Narrator (voice) / Anti-Feminist Author (voice)
Daran Norris
Scummy Guy
Neil Brown Jr.
Jeff Fischer (voice) / Kidnapper (voice) / Donnie Patterson (voice)
Jeff Fischer
Student
Ryan Kyler Bailey
Korean Spy
Hong Chau
Connie
Connie Britton
Esther Lonstein (voice)
Susie Essman
Townsperson
Kasey Bell
Gina (voice) / Airport Terminal Announcer (voice) / The Babe (voice)
Heather Anne Campbell
(voice) / Joe Chandler (voice) / Ragi Baba Follower (voice)
Joe Chandler
Vince Chung (voice)
John Cho
Enoch
Walton Goggins
Nicki Minaj
Daniele Gaither
Puddin'
Jim Rash
(voice) / Boy (voice) / Camper (voice)
Max Charles
Police Officer (voice) / Zach / Man (voice)
David Herman
Donkeyballs
H. Michael Croner
Various
Nickie Bryar
Sky Crooner (voice) / Groom (voice)
Tommy Blacha
Flight Attendant
Olivia d'Abo
Caroline
Jennifer Coolidge
Himself
Johnny "Bananas" Devenanzio
Parker (voice) / (voice) / Piano Player (voice)
Parker Deay
Kid
Bella Laudiero
Stacey
Judy Greer
Jesse
Dermot Mulroney
Lonnie Bolmenferg (voice) / Big Buy Employee (voice) / Vance (voice)
Eric Edelstein
Film Actor
James Remar
Other Side of the Lake Man
Rob Corddry
Derrick
Colin Ford
Tow Truck Driver
Alfred Molina
Jackson (voice) / Jackson / Charlie (voice)
Mike Henry
Suze (voice) / Trish the Waitress (voice) / Hannah (voice)
June Diane Raphael
Himself
Colin Cowherd
Mateo
Wiz Khalifa
Justin
Justin Felbinger
Dick Reynolds (voice) / Wilbur Kentucky (voice) / Dick
David Koechner
Memphis Stormfront (voice) / Bar Bro (voice) / Old Man (voice)
Andrew Daly
Chad
Ryan Hansen
Lil Stinker
John Gemberling
Principal Lewis (voice) / Billy (voice) / Principal Lewis
Kevin Michael Richardson
Announcer
Corey Feldman
Al Tuttle (voice) / Car Salesman (voice)
Richard Kind
Cousin Patrick/Cousin Clifton
Jared Gertner
(voice) / Sub Hub Employee (voice) / Cowboy Hat Girl (voice)
Lauren Lapkus
Film Actor
Andrew Santino
Football Fan
Rachel Butera
Camper
Collin Dean
Cindy
Halsey
Townsperson
Tom Root
Duper (voice)
Phill Lewis
Waiter
Marshall Fox
Barry Robinson (voice) / Barry Robinson / Spike (voice)
Eddie Kaye Thomas
Buck (voice) / Dennis (voice) / Mr. Collins
Tom Hollander
Leon / Brad (voice) / Carl (voice)
John DiMaggio
Vincent Edmonds
Corey Stoll
(voice) / Dawson Family Member (voice) / Fitzwilliam Darcy
Chris Diamantopoulos
Veterinarian
Brian Huskey
Left Handed Kid
Troy Gentile
Himself
Bear Grylls
Karen
Natasha Leggero
(voice) / Wayne Gretzky (voice) / Jerry Seinfeld (voice)
Josh Robert Thompson
Aunt Jesse
Allison Janney
Pool Kid
Matthew McCann
(voice) / Dr. Weitzman (voice) / Alien (voice)
Matt E. Mixer
Sharon
Melanie Lynskey
Terry Bates (voice) / (voice) / Sanders (voice)
Mike Barker
Sam Hanna
LL Cool J
Dr. Kalgary (voice) / (voice) / Doctor (voice)
Alan Tudyk
Himself
Phil Keoghan
Chef Haruki
Tohoru Masamune
Bonnie Sanders / Nurse (voice) / Scottie's Mom (voice)
Wendi McLendon-Covey
(voice) / Student (voice) / Townsperson (voice)
Jeff Kauffmann
(voice) / Mertz (voice) / Townsperson (voice)
Judah Miller
Strannix
Bill Fagerbakke
Matt E. Mixer
G. Callen
Chris O'Donnell
Nurse Margaret (voice) / Phyllis (voice) / Enuice (voice)
Laraine Newman
Himself
Rick Steves
(voice) / Old Woman (voice) / Mom
Jill Talley
Mark
Michael Showalter
Mrs. Hemingway
Rhea Seehorn
Islander
Toks Olagundoye
Demon Sportscaster
Matt Iseman
Trish (voice) / Trish / Molly (voice)
Casey Wilson
Truck Driver (voice) / Gay Man (voice) / Mervyn (voice)
Brett Gelman
Inspector
Kurt Fuller
Marshall
Ryan O'Flanagan
(voice) / Kid with Adult Voice (voice) / Stadium Announcer (voice)
Maurice LaMarche
DelMonaco (voice) / Jake (voice) / White Francine (voice)
Andy Richter
Enzo Perotti
Tony Sirico
(voice) / Tow Truck Driver (voice) / ER Doctor (voice)
Fred Tatasciore
Caroline Duffy
Lea Thompson
Saleswoman
Janie Haddad Tompkins
Himself
Curtis Stone
Raymond (voice) / Police Dispatch (voice) / Trey (voice)
Thomas Lennon
Camper
Matthew McCann
Daisuke Suzuki
Kashi (voice) / Co-Worker (voice) / Sleep Apnea Research Scientist (voice)
Nic Wegener
Toshi Yoshida (voice)
Daisuke Suzuki
Cyrus Mooney
George Lowe
Girl (voice) / Student (voice) / Larry's Wife (voice)
Dreama Walker
Student
Kiernan Shipka
Townie
Rosie O'Donnell
Ashley Tisdale
Rolando Molina
(voice) / Student (voice) / Puppet Guy (voice)
Alex Cuthbertson
Esther Lonstein (voice) / Danuta (voice) / Commercial Wife (voice)
Nicole Shabtai
(voice) / Reginald (voice) / Crisp's Henchman (voice)
Erik Durbin
James Garfield (voice) / Co-Worker (voice) / (voice)
Chris Parnell
(voice) / CIA Guy (voice) / Kidnapper (voice)
Jonathan Fener
(voice) / Leonard Zane (voice) / Judge (voice)
André Sogliuzzo
Tom (voice) / (voice) / Rogu (voice)
Josh Fadem
(voice) / Student (voice) / Various (voice)
Matt Fusfeld
(voice) / Anti-Christ (voice) / The Slow Janitor (voice)
Murray Miller
Coach Cathy (voice) / Elizabeth Bennet (voice) / Woman Carrying Dog (voice)
Courtenay Taylor
Security Guard (voice) / (voice) / Island Sheriff (voice)
Gary Anthony Williams
Porno Director (voice) / Prison Guard (voice) / Bus Driver (voice)
Khary Payton
Co-Worker (voice) / Eric Jermesian III (voice) / Jo-Jo (voice)
Tom Kenny
Colby (voice) / Scotty (voice) / Sanjay Bhudapar (voice)
Amir Talai
Father Donovan (voice)
Martin Mull
(voice) / Hospital Doctor (voice) / Ugly Stepsister #3 (voice)
Marissa Jaret Winokur
Pete Krachowski (voice) / Amish Man (voice) / Elijah (voice)
Joe Lo Truglio
Craig Robinson (voice) / (voice) / Sub Hub Employee (voice)
Craig Robinson
Dick (voice) / Dick / Dentist's Father (voice)
Stephen Root
(voice)
Erik Sommers
(voice) / Dr. Grossbard / Senator #1 (voice)
Peter Mackenzie
Betty Smith (voice) / Marylin Thacker (voice)
Swoosie Kurtz
Mah Mah (voice) / Mah Mah Ling / Helen (voice)
Amy Hill
Butt Insurance Salesman (voice) / Jesus Christ (voice) / Mayor Woodside (voice)
Will Forte
Mother (voice) / Chief of Police (voice) / Timmy's Mom (voice)
Jane Lynch
Police Officer (voice) / Harvey Lissel (voice) / Coach Melonis (voice)
Rob Riggle
Doctor (voice) / Roy Family (voice) / Security Guard (voice)
John Viener
Artemis (voice) / Curly Neal (voice) / Exterminator (voice)
Phil LaMarr
(voice) / Fruit Cart Man (voice) / Columbian Villager (voice)
Ignacio Serricchio
Officer Caruso (voice) / Police Officer (voice) / Bashir Salahuddin
Bashir Salahuddin
Airport Security Guard (voice) / Radio Station Security Guard (voice) / Guy #1 (voice)
J.B. Smoove
Costgo Employee (voice) / Andy Dick (voice) / Dry Cleaner (voice)
Nick Kroll
(voice) / Fat Kid (voice) / Palin's Aide (voice)
Eric Edwards
(voice) / Additional Voices (voice) / Steve's impressions (voice)
Asa Taccone
Sebastian Hub (voice) / Country Bumpkin (voice) / Columbian Villager (voice)
Carlos Alazraqui
Cuban Soldier in Dream / Theodore (voice) / Police Officer (voice)
Jason Mantzoukas
Debbie (voice)
Lizzy Caplan
Sharri Rothberg (voice)
Lisa Edelstein
(voice)
Laura McCreary
Ray (voice)
Victor Raider-Wexler
Connie Robinson (voice) / Doctor (voice)
Jessica St. Clair
Lorraine (voice) / Patty LaBelle (voice) / Angel (voice)
Niecy Nash
(voice) / Henchman (voice) / CIA Guy (voice)
Kevin Durand
Hiko Yoshida (voice) / Katie (voice)
Sandra Oh
Rick Rod (voice) / Cinema Ticket Man (voice) / Candy Maker (voice)
Patton Oswalt
Coconut Vendor (voice) / Omar (voice) / Adoptive Father (voice)
Fred Savage
Courtney (voice) / O'Shamus McPherson (voice) / Wesley Snipes (voice)
J. Lee
(voice) / TRF Agent (voice) / Big Ed (voice)
Rob Huebel
(voice) / Various (voice) / Carl
Steve Hely
Shoshanna (voice) / Pharmacist (voice) / Veterinarian (voice)
Michaela Watkins
(voice) / Tex / Driver (voice)
John Ennis
Robert Wuhl (voice)
Robert Wuhl
Dr. Ray Petit (voice)
Ted Danson