Ingrid Withers

Michelle Pfeiffer

Nurse Aimee

Halle Berry

Stan Harris

Robert De Niro

Paul

Zac Efron

Tess Byrne

Jessica Biel

Caring Teenage Girl

Charlotte Marshall-Fricker

Claire Morgan

Hilary Swank

Jensen

Jon Bon Jovi

Hailey

Abigail Breslin

Murray

Michael Mandell

Brendan

Chris "Ludacris" Bridges

Randy

Ashton Kutcher

Sam

Josh Duhamel

Kominsky

Hector Elizondo

Stan's Doctor

Cary Elwes

Nurse Mindy

Alyssa Milano

Laura

Katherine Heigl

Spiritual Dr. Morriset

Carla Gugino

Griffin Byrne

Seth Meyers

Elise

Lea Michele

Kim Doyle

Sarah Jessica Parker

Ava

Sofía Vergara

James Schwab

Til Schweiger

Grace Schwab

Sarah Paulson

Himself

Ryan Seacrest

Soldier

Common

Sienna Miller

Lily Bowman

Katherine McNamara

Balinese Woman

Fiona Choi

Pet Adoption Clerk

Mary Marguerite Keane

Seth

Jake T. Austin

Penny Marshall

Penny Marshall

Times Square Cop

Patrick Reale

Walter

Nat Wolff

Maude

Yeardley Smith

Head Nurse Helen

Barbara Marshall

Himself

Michael Bloomberg

Nurse Risa

Amber Bela Muse

Building Super

Jim Belushi

Male Nurse

Peter Allen Vogt

Mika

Mara Davi

Piper

Cassidy Reiff

Pedicab Driver

Ross Ryman

Male Obstetrician

Kal Parekh

Chef Sunil

Russell Peters

Chef Ming

Serena Poon

Soldier

Lonnie Rashid Lynn Jr.

Monty

Sarge

Bride Trish

Jackie Seiden

Groom Rory

Joey McIntyre

Mrs. Lifflander

Lillian Lifflander

Piper's Mom

Beth Kennedy

Harley (segment "Ahern Party")

Larry Miller

Waitress Alyssa

Christine Lakin

Choreographer

Jaclyn Miller

Wendy

Shea Curry

Patty

Sandra Taylor

Mr. Buellerton (uncredited)

Matthew Broderick

Kelly

Kendra Jain

Jonathan Cox (uncredited)

John Lithgow

Julia

Julia Randall

Cody

Christian Fortune

Tatyana

Tatyana Disla

Chealy

Chealy Phuong

Vendor Marvin

Marvin Braveman

Screaming Rocker Girl

Alexandra Rose Guthy

Female Cop Denise

Denise Violante

Newark Commuter

Norman Bukofzer

Pastor Edwin

Sean O'Bryan

Grandpa Jed

Jack Mcgee

Logan

Benjamin McGowan

Duncan

Jon-Christian Costable

Sadie

Juliette Allen-Angelo

Ahern Waitress

Drena De Niro

Leopard Print Girl

Vanessa Mendoza

Pianist

Earl Rose

Male Party Guest

Johnny Debrito

Penny's Dance Partner

Samuel Mitchell

Party Dancer

Amare Stoudemire

Mrs. Rose Ahern

Cherry Jones

Stage Manager Charlotte

Kathleen Marshall

Radio Reporter Arthur

Joey Sorge

Officer Nolan

Rob Nagle

Engineer Douglas

Matthew Walker

Reporter Christina

Wedil David

Reporter Murphy

David Valcin

Reporter Lupe

Stephanie Fabian

Reporter Fadda

Patrick Collins

Reporter Pat Battle

Pat Battle

Announcer Brady Finley

Tom Hines

Wade the Aide

Greg Wilson

Ginger Adams

Anna Aimee White

Crowd Surfing Kid

Sam Marshall

Bunny Friedberg

Susan Silver

Crazy Jensen Fan

Emily Moss Wilson

Jensen Concert Police

Bob Weston

Backup Singer

Lucy Woodward

Backup Singer

Stephanie Alexander

Kissing Reveler #1

Nicole Sobchack

Kissing Reveler #2

Anna Kulinova

Kissing Female Cop

Rylie J. Neale

Reveler Lucy Camille

Lily Marshall-Fricker

Reveler Ms. Camille

Lori Marshall

David

Stephen Mangan

Leah

Keira Knightley

Paul

Philip Herbert

Michael

Bohdan Poraj

Hanna

Naomi Allisstone

Flirty Helen

Elizabeth Chadwick

Little Boy

Cameron Cuffe

Champagne Lady

Janet Hargreaves

Jane

Valerie Farr

Party Guest

Merle Newell

Mrs. Brendan

Shikha Jain

Christian

LeRoy Mobley

Chris Bridges

Director

Garry Marshall

Director

Col Spector