Charlie Harper

Charlie Sheen

Alan Harper

Jon Cryer

Jake Harper

Angus T. Jones

Berta

Conchata Ferrell

Judith

Marin Hinkle

Evelyn Harper

Holland Taylor

Jamie Eckleberry

Paget Brewster

Christine

Gigi Rice

Dr. Michelle Talmadge

Alicia Coppola

Sean Penn

Sean Penn

Rose

Melanie Lynskey

Heather

Cynthia Preston

Danielle

Catherine McCord

Debbie

Kristen Miller

Very Tall Guy in Movie Theater

Scott Barrows

Norman

Orson Bean

Minister

Steve Tom

Kimberly

Christina Chambers

Sherri

Jeri Ryan

Male Nurse

Ken Jeong

Pamela

Lucy Lawless

Elvis Costello

Elvis Costello

Daisy Ray

Camryn Manheim

Trudy

Chloe Webb

Dr. Little

Bob Morrisey

Delores Pasternak

Missi Pyle

Walden Schmidt

Ashton Kutcher

Nurse

Helen Greenberg

Harry Dean Stanton

Harry Dean Stanton

Stephan "Bobby"' Wasserstein

James Edson

Little Alan

Daniel Sheldon

Natalie

Karen Trella

Nancy

Kelley West

Gail

Jodi Lyn O'Keefe

Herb / Dr. Melnick

Ryan Stiles

Eric

David Starzyk

Lisa

Denise Richards

Anesthesiologist

Suzanne Whang

TV Narrator

Brian George

Megan

Audrey Wasilewski

Tina

Jennifer Taylor

TV Narrator

Nick Toth

Doctor

Mark Chaet

Bobby Cooper

Bobby Cooper

Mrs. Flanagan

Patricia Bethune

Little Charlie

Dylan Minnette

Cab Driver

Jack Harick

Lyndsey Mackelroy

Courtney Thorne-Smith

Camille

Nicole Forester

Lisa's Daughter

Sami Sheen

Shopper

Dayna Devon

Montage Beautiful Woman

Julie Dickens

Waiter

John O'Brien

Inga

Magdalena Holland

Newscaster

Ted Garcia

Montage Doctor

Ana Alexander

Anchor

Leyna Nguyen

Girl on Answering Machine

Nicole Foster

Cab Driver

Jay Harik

Jenny

Amber Tamblyn

Zoey

Sophie Winkleman

Eldridge Mackelroy

Graham Patrick Martin

Dr. Linda Freeman

Jane Lynch

Bridget Schmidt / Myra / Danny

Judy Greer

Mia

Emmanuelle Vaugier

TV Announcer (voice) / Announcer / Pilot (voice)

Robert Clotworthy

Melissa

Kelly Stables

Larry

D. B. Sweeney

Ms. McMartin

Maggie Lawson

Gordon / Ted

J.D. Walsh

Kate / Robin

Brooke D'Orsay

Leanne

Rebecca McFarland

Courtney

Jenny McCarthy-Wahlberg

Barry

Clark Duke

Michelle DiBenedetti

Robin Schmidt

Mimi Rogers

Gretchen

Kimberly Williams-Paisley

Russell

Martin Mull

Teddy

Robert Wagner

Linda

Ming-Na Wen

Billy Stanhope

Patton Oswalt

Brooke

Aly Michalka

Nick / Petey / Doug

Joel Murray

Ava

Talyan Wright