Captain Spaulding

Sid Haig

Otis Driftwood

Bill Moseley

Baby Firefly

Sheri Moon

Jerry Goldsmith

Chris Hardwick

Denise Willis

Erin Daniels

Mother Firefly

Karen Black

Grampa Hugo

Dennis Fimple

Mary Knowles

Jennifer Jostyn

Bill Hudley

Rainn Wilson

Steve Naish

Walton Goggins

Lieutenant George Wydell

Tom Towles

Tiny Firefly

Matthew McGrory

Rufus

Robert Mukes

Don Willis

Harrison Young

Sheriff Huston

William H. Bassett

Ravelli

Irwin Keyes

Stucky

Michael J. Pollard

Rufus 'Earl' Firefly Sr.

Jake McKinnon

Richard Wick

David Reynolds VII

Gerry Ober

Joe Dobbs III

Killer Karl

Chad Bannon

Jeanne Carmen

Skunk Ape Wife

Judith Drake

Richard 'Little Dick' Wick

David Reynolds

Skunk Ape Husband

Ken Johnson

Dr. Wolfenstein

Gregg Gibbs

Lewis Dover

Irvin Mosley Jr.

Dr. Satan

Walter Phelan

Donald Paul Pemrick

Dr. Wolfenstein's assistant (uncredited)

Rob Zombie

Dean Fronk

Walton

Mental Patient

Johnny Hoops

Sex slave

Samantha Larsen

Tow Truck Driver

Bob Pepper

Mental Patient

Freddy Waff