Charlie Harper

Charlie Sheen

Alan Harper

Jon Cryer

Evelyn Harper

Holland Taylor

Jake Harper

Angus T. Jones

Berta

Conchata Ferrell

Kate

Liz Vassey

Judith Harper

Marin Hinkle

Tommy Pearson

Madison Mason

Laura Lang

Heather Locklear

Miss Tuttle

Deena Dill

Frankie

Jenna Elfman

Gloria

Christine Dunford

Bill/Jill

Chris O'Donnell

Olivia Pearson

Krista Allen

Rose

Melanie Lynskey

Wendy

Myndy Crist

Cindy

Kristin Dattilo

Stuart

Marc Grapey

Brianna

Abigail Mavity

Brooke

Tricia O'Kelley

Joanie

Juliette Goglia

Laura

Kristin Bauer*

Bill

Eric Allan Kramer

Desiree Barrington

Johanna Black

Dave

Christopher Jacobs

Dr. Linda Freeman

Jane Lynch

Dr. Prajneep

Kris Iyer

Rodney

Frankie J. Allison

Andrew

Sam Lerner

Prudence

Megan Fox

Guest Star

Sian Heder

Liz

Teri Hatcher

Leanne

Rebecca McFarland

Cab Driver

Darryl Sivad

Lisa

Denise Richards

Kathy

Lori Lively

Stan

Richard Lewis

Nurse

Vernee Watson Johnson

Walden Schmidt

Ashton Kutcher

Dr. Andrew Sperlock

Terry Rhoads

Guest Star

Rhyon Brown

Guest Star

Romy Rosemont

Crystal

Alana De La Garza

Phil

John Valdetero

Vicki

Amanda Tosch

Darlene

Amanda Swisten

Steven Tyler

Steven Tyler

Lenny

Eugene Byrd

Ernie

Zachary Polmanteer

Freddie

Noel Fisher

Sheldon

George Wyner

Ruth

Cheryl White

Karen

Louisette Geiss

Naomi

Jenna Gering

Katie

Katelin Petersen

Annette

Jamie Day

Second Nurse

Elise Robertson

Richard

Daniel Escobar

Susan

Elena Lyons

Lyndsey Mackelroy

Courtney Thorne-Smith

Lenore

Cristine Rose

Kathleen

Amy Farrington

Cheryl Ann

Lisa Arning

Debbie

Steffani Brass

Paul

Byrne Offutt

Doug

Eddie Gorodetsky

Gordon / Ted

J.D. Walsh

Luis

Jacob Urrutia

Gonzales

Ski Carr

Kevin

Lucky Vanous

Chelsea / Suzanne / Tina

Jennifer Taylor

Football Announcer

Nick Toth

Mandy

Yvette Nicole Brown

Class Mom

LeeAnn Powers

Lauren

Kristin Bauer van Straten

Tiffany

Kristin Richardson

Herb / Dr. Melnick

Ryan Stiles

Lacey

Elizabeth Schaible

Linda

Stacey Travis

Mike

Thomas F. Wilson

Jenny

Amber Tamblyn

Zoey

Sophie Winkleman

Ken

Dan Foster

Eldridge Mackelroy

Graham Patrick Martin

Bridget Schmidt / Myra / Danny

Judy Greer

Mia

Emmanuelle Vaugier

TV Announcer (voice) / Announcer / Pilot (voice)

Robert Clotworthy

Melissa

Kelly Stables

Larry

D. B. Sweeney

Ms. McMartin

Maggie Lawson

Kate / Robin

Brooke D'Orsay

Courtney

Jenny McCarthy-Wahlberg

Barry

Clark Duke

Stephan 'Bobby' Wasserstein

James Edson

Robin Schmidt

Mimi Rogers

Gretchen

Kimberly Williams-Paisley

Russell

Martin Mull

Teddy

Robert Wagner

Linda

Ming-Na Wen

Billy Stanhope

Patton Oswalt

Brooke

Aly Michalka

Nick / Petey / Doug

Joel Murray

Ava

Talyan Wright