Meg

Storm Reid

Mrs. Which

Oprah Winfrey

Mrs. Whatsit

Reese Witherspoon

Mrs. Who

Mindy Kaling

The Happy Medium

Zach Galifianakis

Mrs. Murry

Gugu Mbatha-Raw

Red

Michael Peña

Alexander Murry

Chris Pine

Calvin O'Keefe

Levi Miller

Charles Wallace Murry

Deric McCabe

Camazotz Woman

Bellamy Young

Principal Jenkins

André Holland

Veronica Kiley

Rowan Blanchard

The It (voice)

David Oyelowo

Elegant Man

Conrad Roberts

Mrs. Teacher

Yvette Cason*

Young Meg

Lyric Wilson

Mr. Teacher

Will McCormack

Calvin's Father

Daniel MacPherson

Air Force Officer

Akemi Look

School Superintendent

Tim Kang

Radio News Broadcaster (voice)

Michele Norris

Student

Claire Montwill

Baby Charles Wallace

Easton Tath

Baby Charles Wallace

Giselle Paredes

Meg Double

Catelynn Brown

Meg Double

Ariyah Brown

Meg Double

Losa Fifita

Mrs. Who Double

Joyce Larkin

Mrs. Which Double

Teonee Motley

Mrs. Whatsit Double

Jessica Rockwell

Charles Wallace Double

Oz Kalvan

Charles Wallace Double

Isaac Ordonez

Charles Wallace Double

Kai Miller

Charles Wallace Double

Leighton Leevard

Charles Wallace Double

Guillaume Seeleuthner

Charles Wallace Double

Jacob Eddington