Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Adriatica Veljohnson/CBSBN Exec/Dubya/Flight Attendant

Tress MacNeille

Himself

Ted Nugent

Robert Marlowe

John Slattery

Stradivarius Cain

Bryan Cranston

Robots

Brent Spiner

Wayne

Kiefer Sutherland

Nick

Michael Cera

Roz Davis

Jane Lynch

Amus Bruse

Tim Heidecker

Annie Dubinsky

Joan Rivers

Mona Simpson (voice)

Glenn Close

Himself

Neil Gaiman

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Cameron Winklevoss / Tyler Winklevoss

Armie Hammer

Herself

Lady Gaga

Himself

Shepard Fairey

911 Dispatcher

Aron Ralston

Herself

Alison Krauss

Himself

Treat Williams

Bar Rag

Jeremy Irons

Himself (archive footage)

Theodore Roosevelt

Performer - 'Dream Operator'

David Byrne

Declan Desmond

Eric Idle

Businessman

Matthew Weiner

Himself

Jamie Hyneman

Fois Garth

Eric Wareheim

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Slick Publisher

Andy Garcia

Himself

Tom Colicchio

Himself

Ron English

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Himself

David Letterman

Rowan Priddis

Steve Coogan

Themselves

Union Station

Additional Voices

Bill Plympton

Himself

Adam Savage

Herself

Janeane Garofalo

Himself

Anthony Bourdain

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Himself

Kenny Scharf

Himself

Julian Assange

Soccer Presenter

Matt Groening

Norbert Gastell

Additional Voices

Renee Ridgeley

Himself

Gordon Ramsay

Himself

Kevin Dillon

Himself

Robbie Conal

Sideshow Bob (voice)

Kelsey Grammer

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott*

Himself

Mario Batali

The Tiger Lillies

Adrian Hughes

Hyman Krustofsky (voice)

Jackie Mason

Anke Engelke

Victor

Ping Marshall

Sandra Schwittau

The Tiger Lillies

Martyn Jacques

The Tiger Lillies

Adrian Stout

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Rayshelle Peyton (voice)

Kerry Washington

Milhouse Van Houten (voice)

Kelly Macleod

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Baboons (voice) / Santa's Little Helper / Mr. Teeny

Frank Welker

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow