Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bart Simpson/Nelson Muntz/Todd Flanders/Ralph Wiggum/Kearney

Nancy Cartwright

Lisa Simpson (voice)

Yeardley Smith

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Himself

Mel Gibson

Jim Hope

Tim Robbins

Herself

Britney Spears

Edward Christian

Jack Burns

Herself

Nancy O'Dell

Herself

Betty White

Larry Kidkill

Garry Marshall

Himself

Kid Rock

Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

Meathook

John Goodman

Himself

Fred Turner

Herself

Lucy Lawless

Himself

Tom Arnold

Himself

Pat O'Brien

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Additional Voices (voice) / (voice) / Prisoners

Karl Wiedergott*

Ramrod

Henry Winkler

Himself

Randy Bachman

Himself

Joe C.

Guest Voice

Ed Asner

Brother Faith

Don Cheadle

Himself

Gary Coleman

Herself

Kate Pierson

Himself

Butch Patrick

Virtual Doctor

Elwood Edwards

Agnes Skinner (voice) / Dolph (voice) / (voice)

Tress MacNeille

Drummer

Marc Wilmore

Himself

Fred Schneider

Himself

Trevor Denman

Themselves

NRBQ

Rachel Jordan

Shawn Colvin

Himself

Dick Clark

Himself

Robert Evans

Himself

Ron Howard

Himself

Keith Strickland

Himself

Willie Nelson

Becky

Parker Posey

Dunkin

Jim Cummings

Himself

Charlie Rose

Himself

Penn Jillette

Officer

Diedrich Bader

Himself

Teller

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Herself

Cindy Wilson

Narrator

Clarence Clemons

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Norbert Gastell

Monkeys / Princess (voice) / Executive Vice-President (voice)

Frank Welker

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Himself

Jay North

Himself (archive footage)

Tom Kite

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Himself (archive footage)

Stephen Hawking

Himself

Mark McGwire

Narrator

Jim Forbes

Sandra Schwittau

Dr. Hibbert (voice) / Narrator (voice) / Jay G (voice)

Kevin Michael Richardson

Helen Lovejoy (voice) / Maude Flanders (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Himself (archive footage)

Buzz Aldrin

Sideshow Bob (voice)

Kelsey Grammer

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Bernice Hibbert (voice) / (voice) / Cannabis Influencer (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / Chef Naziwa

Maurice LaMarche

Llewellyn Sinclair (voice) / Artie Ziff (voice) / Enrico Irritazio (voice)

Jon Lovitz

Mona Simpson (voice)

Glenn Close

Kumiko Albertson (voice) / Truth-Anne (voice) / Band Student (voice)

Jenny Yokobori

Hyman Krustofsky (voice)

Jackie Mason

Jacques (voice) / Hank Scorpio (voice) / Tab Spangler

Albert Brooks

Julio Franco (voice) / Julio (voice) / Audience

Tony Rodriguez

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Lewis Clark (voice) / Janine Powell (voice) / Kindergartener (voice)

Kimberly Brooks

Lunchlady Doris (voice) / Ice cream lady (voice) / Della (voice)

Doris Grau

Susan / Collette the Waitress (voice) / Weasel #2

Jo Ann Harris

Rayshelle Peyton (voice)

Kerry Washington

Backstage Mom (voice) / Mrs. Butterworth (voice) / Old Lady (voice)

Valerie Harper

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Murphy (voice) / Dana Gould (voice) / I.N.S. Agent (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Clayton (voice)

Michael York

Bumblebee Man (voice) / Lisa's Student (voice) / Gambling Old Man (voice)

Eric Lopez

Sarah Wiggum (voice)

Megan Mullally

Akira Kurosawa (voice) / Wink - The Game Show Host (voice) / Waiter (voice)

George Takei

J. Jonah Jameson (voice) / Victor Kleskow (voice) / Tabloid Editor (voice)

J.K. Simmons