Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/ Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bart Simpson/Nelson Muntz/Todd Flanders/Ralph Wiggum/Kearney

Nancy Cartwright

Lisa Simpson (voice)

Yeardley Smith

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Dr. Julius Hibbert/Reverend Timothy Lovejoy

Harry Shearer

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Himself

Mel Gibson

Jim Hope

Tim Robbins

Herself

Britney Spears

Edward Christian

Jack Burns

Herself

Nancy O'Dell

Herself

Betty White

Larry Kidkill

Garry Marshall

Himself

Kid Rock

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Meathook

John Goodman

Himself

Fred Turner

Herself

Lucy Lawless

Himself

Tom Arnold

Himself

Pat O'Brien

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott

Ramrod

Henry Winkler

Himself

Randy Bachman

Himself

Joe C.

Guest Voice

Ed Asner

Brother Faith

Don Cheadle

Himself

Gary Coleman

Herself

Kate Pierson

Himself

Butch Patrick

Virtual Doctor

Elwood Edwards

Agnes Skinner (voice) / (voice) / Dolph (voice)

Tress MacNeille

Drummer

Marc Wilmore

Himself

Fred Schneider

Himself

Trevor Denman

Themselves

NRBQ

Rachel Jordan

Shawn Colvin

Himself

Dick Clark

Himself

Robert Evans

Himself

Ron Howard

Himself

Keith Strickland

Himself

Willie Nelson

Becky

Parker Posey

Dunkin

Jim Cummings

Himself

Charlie Rose

Himself

Penn Jillette

Officer

Diedrich Bader

Himself

Teller

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Herself

Cindy Wilson

Narrator

Clarence Clemons

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Norbert Gastell

Barnyard Animals

Frank Welker

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Himself

Jay North

Himself (archive footage)

Tom Kite

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Himself (archive footage)

Stephen Hawking

Himself

Mark McGwire

Narrator

Jim Forbes

Sandra Schwittau

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Himself (archive footage)

Buzz Aldrin

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Sideshow Bob (voice)

Kelsey Grammer

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Mona Simpson (voice)

Glenn Close

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Hyman Krustofsky (voice)

Jackie Mason

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Rayshelle Peyton (voice)

Kerry Washington

Milhouse Van Houten (voice)

Kelly Macleod

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow