Vanessa

Morena Baccarin

Wade/Deadpool

Ryan Reynolds

Ajax

Ed Skrein

Angel Dust

Gina Carano

Weasel

T.J. Miller

Ellie Phimister / Negasonic Teenage Warhead

Brianna Hildebrand

Jeremy

Style Dayne

Weasel

T. J. Miller

Blind Al

Leslie Uggams

Piotr Rasputin/Colossus

Andre Tricoteux

Meghan Orlovsky

Taylor Hickson

Flight Deck Guard

Paul Lazenby

Dopinder

Karan Soni

Recruiter

Jed Rees

Colossus (voice)

Stefan Kapičić

No5 Orange Manager

Ben Wilkinson

Gavin Merchant

Kyle Cassie

David Cunningham

Hugh Scott

Buck

Randal Reeder

Teen Girl #1

Ayzee

Warlord

Michael Benyaer

Boothe

Isaac C. Singleton Jr.

Teen Girl #2

Naika Toussaint

Arcade Ticket Taker

Justyn Shippelt

Oncologist

Donna Yamamoto

Chinatown Merchant

Cindy Piper

Whisper Girlfriend

Emily Haine

Whisper Boyfriend

Amir Aatash

Pool Hall Goon

Chad Riley

Fight Club Boss

Paul Belsito

Garbage Truck Driver

Darcey Johnson

Super Soldier #1

Kyle Rideout

Whisper Boyfriend

Aatash Amir

Super Soldier #2

Jason Day

Strip Club DJ

Stan Lee

Strip Club Worker

Rachel Shaw

Bob

Rob Hayter

Super Soldier #2

Jason William Day

Sean Quan

Biker

Dan Zachary

Strip Club Worker

Rachel Sheen

Director

Lauren Shuler-Donner

Director

Tim Miller