Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Marie Simpson

Yeardley Smith

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Reverend Timothy Lovejoy

Harry Shearer

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Agnes Skinner (voice) / Dolph (voice) / (voice)

Tress MacNeille

Gus

John Lithgow

Self

Tree Rollins

Janitor

Hugh Jackman

Marge's head voice

Kristen Bell

Norse Deity/Loki

Alan Cumming

Mona Simpson (voice)

Glenn Close

Seamus

Chris O'Dowd

Grayson

Beck Bennett

Theo

Kumail Nanjiani

Orion Hughes/Darius Hughes

Abel "The Weeknd" Tesfaye

Michael

Victor Garber

Monk

John Autry II

Self

Adam Schefter

Sheila

Krysten Ritter

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Mike Wegman

Michael Rapaport

Kostas Becker

Brian Cox

himself

Robert Reich

Therapist #3

Rachel Bloom

Female Voice/Sasha

Sara Chase

Herself

Christine Baranski

Sports Anchor

Scott Hanson

Jessica

Edi Patterson

Young Woman

Grey Griffin

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Himself

Christian Siriano

Barb

Cristin Milioti

Warburton Parker

John Mulaney

Fat Tony (voice) / Gordus Antonius (voice)

Joe Mantegna

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Mav

Seth Green

Bill Cipher

Alex Hirsch

Colby

Paul F. Thompkins

Additional Voices (voice) / (voice) / Prisoners

Karl Wiedergott*

Collette

Jessica Paré

Sheriff Flanders

Timothy Olyphant

Cousin Greg

Nicholas Braun

Self

Charli D'Amelio

Dr. Hibbert (voice) / Narrator (voice) / Jay G (voice)

Kevin Michael Richardson

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Sideshow Bob (voice)

Kelsey Grammer

Bernice Hibbert (voice) / (voice) / Cannabis Influencer (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / Chef Naziwa

Maurice LaMarche

Llewellyn Sinclair (voice) / Artie Ziff (voice) / Enrico Irritazio (voice)

Jon Lovitz

Kumiko Albertson (voice) / Truth-Anne (voice) / Band Student (voice)

Jenny Yokobori

Hyman Krustofsky (voice)

Jackie Mason

Helen Lovejoy (voice) / Maude Flanders (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Jacques (voice) / Hank Scorpio (voice) / Tab Spangler

Albert Brooks

Julio Franco (voice) / Julio (voice) / Audience

Tony Rodriguez

Constance Harm (voice) / Judge Harm (voice)

Jane Kaczmarek

Lewis Clark (voice) / Janine Powell (voice) / Kindergartener (voice)

Kimberly Brooks

Lunchlady Doris (voice) / Ice cream lady (voice) / Della (voice)

Doris Grau

Susan / Collette the Waitress (voice) / Weasel #2

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Rayshelle Peyton (voice)

Kerry Washington

Backstage Mom (voice) / Mrs. Butterworth (voice) / Old Lady (voice)

Valerie Harper

Monkeys / Princess (voice) / Executive Vice-President (voice)

Frank Welker

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard Duff (voice)

Stacy Keach

Murphy (voice) / Dana Gould (voice) / I.N.S. Agent (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Clayton (voice)

Michael York

Bumblebee Man (voice) / Lisa's Student (voice) / Gambling Old Man (voice)

Eric Lopez

Stephen Hawking (voice)

Stephen Hawking

Sarah Wiggum (voice)

Megan Mullally

Akira Kurosawa (voice) / Wink - The Game Show Host (voice) / Waiter (voice)

George Takei

J. Jonah Jameson (voice) / Victor Kleskow (voice) / Tabloid Editor (voice)

J.K. Simmons