Aurora Greenway

Shirley MacLaine

Emma Greenway Horton

Debra Winger

Garrett Breedlove

Jack Nicholson

Flap Horton

Jeff Daniels

Vernon Dahlart

Danny DeVito

Sam Burns

John Lithgow

Rosie Dunlop

Betty King

Patsy Clark

Lisa Hart Carroll

Teddy Horton

Huckleberry Fox

Melanie Horton

Megan Morris

Tommy Horton

Troy Bishop

Younger Tommy Horton

Shane Serwin

Young Emma Greenway

Jennifer Josey

Baby Melanie

Tara Yeakey

Edward Johnson

Norman Bennett

Janice

Kate Charleson

Dr. Budge

Tom Wees

Dr. Maise

Paul Menzel

Doctor

F. William Parker

Meg

Amanda Watkins

Dr. Ratcher

Buddy Gilbert

Phil

David Wohl

Nurse

Shelley K. Kielsen

Nurse

Betty Croissant

Nurse

Shelley K. Nielsen

Rudyard's Employer

Charles Beall

Nurse

Bette Croissant

Doris

Lelise Folse

Lee Anne

Sharisse Baker

Checkout Girl

Judith A. Dickerson

Lee Anne

Sharisse Baker-Bernard

Lizbeth

Devon O'Brien

Checkout Girl

Judy Dickerson

Victoria

Dana Vance

Jane

Alexandra O'Karma

Woman at Party

Nancy Mette

T.J.

Holly Beth Holmberg

Jack Stern

Lear Levin

T.J.

Holly Holmberg Brooks

Patsy's Mother

Lanier Whilden

Flap's Secretary

Helen Stauffer

Rudyard Greenway (voice)

Albert Brooks

Woman

Barbara Balik

Woman

Michelle Watkins

Moving Man

John C. Conger

Mrs. Johnson

Sandra Newkirk

Herself

Elaine McGown

Doris (voice)

Mary Kay Place

Director

James L. Brooks