Homer Simpson / Abe Simpson / Barney Gumble

Dan Castellaneta

Marjorie Bouvier Simpson/Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Simpson (voice)

Yeardley Smith

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Moe Szyslak/Apu Nahasapeemapetilon/Chief Clancy Wiggum/Dr. Nick Riviera

Hank Azaria

Charles Montgomery Burns/Waylon Smithers/Principal Seymour Skinner/Ned Flanders/Otto Mann/Scratchy/Kent Brockman/Reverend Timothy Lovejoy

Harry Shearer

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Dolph

Tress MacNeille

Milhouse Van Houten (voice)

Kelly Macleod

Peter Linz

Glenn Howerton

Wayne the Grip

Ike Barinholtz

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

Hub

Kieran Culkin

Accented Voice/Bumblebee Man

Humberto Velez

Merle

Stephen Tobolowsky

Dr. Stern

Matthew Modine

Consonance

Julianne Moore

Joe Quimby Senior

Brendan Gleeson

Profiler

Paget Brewster

Adrienne

Quinta Brunson

Vidalia

Stephanie Hsu

E.R. Nurse

Katherine LaNasa

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Narrator

Viola Davis

Rayshelle Peyton (voice)

Kerry Washington

Himself

Alejandro Iñárritu

Rusty the Piercer

Mike Cullen

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Johnson Bryans

Danny Pudi

Young Joe Quimby Sr.

Domhnall Gleeson

Farley

Zach Cherry

E.R. Intern

Taylor Dearden

The Devil

Idris Elba

Himself

Johnny Knoxville

Stylish Patron

Gary Janetti

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Ben

Adam Pally

Marie MacWeldon-MacDougal

Karen Gillan

Garrett Evanson

Paul Brittain

Devin

Cole Escola

Various

Patricia Acevedo

Hub's Dad

Kurtwood Smith

Hal Julian

Michael Keaton

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Clincher

David Herman

Tour Guide

Questlove

Woman/Beatrice

Carrie Coon

Various

Claudia Motta

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott*

Philly Concierge

Kevin Bacon

Mr. Ho-Hum

Barry Sonnenfeld

Doctor

Noah Wylie

Boyz II Men

Boyz II Men

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Michael Stipe

Michael Stipe

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Sideshow Bob (voice)

Kelsey Grammer

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Mona Simpson (voice)

Glenn Close

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Hyman Krustofsky (voice)

Jackie Mason

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Baboons (voice) / Santa's Little Helper / Mr. Teeny

Frank Welker

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow