Homer Jay Simpson/Barney Gumble/Grampa Simpson/Mayor Joe Quimby/Krusty the Klown/Groundskeeper Willie

Dan Castellaneta

Marjorie Bouvier Simpson/Patty Bouvier/Selma Bouvier/Grandma Jackie Bouvier

Julie Kavner

Bartholomew Jo-Jo "Bart" Simpson/Nelson Muntz

Nancy Cartwright

Lisa Simpson (voice)

Yeardley Smith

Martin Prince (voice) / Martin Prince / Sherri

Russi Taylor

Moe Szyslak / Chief Wiggum / Apu

Hank Azaria

Principal Seymour Skinner/Ned Flanders

Harry Shearer

Milhouse Van Houten (voice) / Milhouse (voice) / Milhouse Van Houten

Pamela Hayden

Dolph

Tress MacNeille

Joel

John Early

Singer/Herself

Sarah McLachlan

Tasha

Chloe Fineman

Himself

Rick Steves

Billy O'Donnell

Topher Grace

Rayshelle Peyton (voice)

Kerry Washington

Constance Harm (voice) / Judge Harm (voice) / Judge Constance Harm (voice)

Jane Kaczmarek

Mona Simpson (voice)

Glenn Close

Lurleen Lumpkin

Beverly D'Angelo

Himself

Robert Parker

Guest Voice

Derren Brown

Aunt Sadie

Susie Essman

Himself

Conan O'Brien

British voice/Julian

Richard E. Grant

Walkov

Jamie Demetriou

Wilhelm von Wonthelm

Mads Mikkelsen

Illustrated Man/Siegfried Blaze

Andy Serkis

Quirk Girl

Zooey Deschanel

Warren Wingspan

John Pirruccello

Wayne the Grip

Ike Barinholtz

Thad

John DiMaggio

Artie Ziff (voice) / Llewellyn Sinclair (voice) / Enrico Irritazio (voice)

Jon Lovitz

Edna Krabappel (voice) / Crowd (voice) / Edna Krabappel

Marcia Wallace

Herself

Ruth Reichl

Himself

John Cena

Guest Voice

Pentatonix

Annette

Rachel Bloom

Sideshow Bob (voice)

Kelsey Grammer

Katya

Molly Shannon

Razelton

Robert Smigel

Self

Danny Trejo

Himself

Tracy Letts

Mrs. McCormick

Fiona Shaw

Schultz

Max Greenfield

Himself

Joel McHale

Maude Flanders (voice) / Luann Van Houten (voice) / Helen Lovejoy (voice)

Maggie Roswell

Himself

Blake Griffin

Self

Tim Meadows

Guest Voice

Patti LaBelle

Self

Kevin Burkhardt

Herb Powell

Danny DeVito

(voice) / Additional Voices (voice) / Laughing Crowd (voice)

Chris Edgerly

Self

Kevin Millar

Herself

Megan Rapinoe

Self

Chris Rock

Additional Voices (voice) / (voice) / Zombie Nurse

Karl Wiedergott*

Himself

Tom Hanks

Himself

Andrew Luck

Reporter

Steve Gelbs

Dr. Hibbert (voice) / (voice) / Narrator (voice)

Kevin Michael Richardson

Carl Carlson (voice) / Lou (voice) / Carl Carlson

Alex Désert

Martin Prince (voice) / Sherri / Terri (voice)

Grey DeLisle

Fat Tony (voice) / Fat Tony / Fat Tony's Former Father (voice)

Joe Mantegna

Troy McClure (voice) / Lionel Hutz (voice) / Lionel Hutz

Phil Hartman

Bernice Hibbert (voice) / (voice) / Court Bailiff (voice)

Dawnn Lewis

Orson Welles (voice) / (voice) / City Inspector (voice)

Maurice LaMarche

Kumiko Albertson (voice) / Truth-Anne (voice) / (voice)

Jenny Yokobori

Lewis Clark (voice) / Janey Powell (voice) / Janine Powell (voice)

Kimberly Brooks

Julio Franco (voice) / Julio (voice) / (voice)

Tony Rodriguez

Hyman Krustofsky (voice)

Jackie Mason

Jacques (voice) / Hank Scorpio (voice) / Slick Manager (voice)

Albert Brooks

Maude Flanders (voice) / Helen Lovejoy (voice) / Miss Hoover (voice)

Marcia Mitzman Gaven

Milhouse Van Houten (voice)

Kelly Macleod

Lunchlady Doris (voice) / Ice cream lady (voice) / Shotgun Pete's Receptionist (voice)

Doris Grau

Weasel (voice) / Martin Prince / Photography Club Member #3

Jo Ann Harris

Manjula Nahasapeemapetilon (voice)

Jan Hooks

Mrs. Butterworth (voice) / Nurse (voice) / Ms. Myles (voice)

Valerie Harper

Bumblebee Man (voice) / (voice) / Gambling Old Man (voice)

Eric Lopez

Baboons (voice) / Santa's Little Helper / Mr. Teeny

Frank Welker

Howard K. Duff VIII (voice) / Don Bookner (voice) / Howard K. Duff VIII

Stacy Keach

Murphy (voice) / I.N.S. Agent (voice) / Dana Gould (voice)

Dana Gould

Dr. Lionel Budgie (voice) / Nigel (voice) / Mason Fairbanks (voice)

Michael York

Sarah Wiggum (voice)

Megan Mullally

Stephen Hawking (voice)

Stephen Hawking

Akira Kurosawa (voice) / George Takei (voice) / Wink - The Game Show Host (voice)

George Takei

Victor Kleskow (voice) / Dr. Jessup (voice) / JJ Gruff (voice)

J.K. Simmons

Axel (voice) / Bull (voice) / Balfalmagog (voice)

Jonathan Lipow