Keyes is as well known for her marriages to, among others, directors Charles Vidor and John Huston and bandleader Artie Shaw, as for her acting. She appeared as one of Scarlett's younger sisters in Gone with the Wind (1939), as well as performances in Union Pacific (1939), Here Comes Mr. Jordan (1941), A Thousand and One Nights (1945), The Jolson Story (1946), The Seven-Year Itch (1955) and Around the World in 80 Days (1957).