Neo ("Kid's Story") (voice)

Keanu Reeves

Trinity ("Kid's Story" and "A Detective Story") (voice)

Carrie-Anne Moss

Additional Voices ("The Second Renaissance Part I & II") / Ash ("A Detective Story") / Raul ("Matriculated")

James Arnold Taylor

The Kid ("Kid's Story") (voice)

Clayton Watson

Jue ("Final Flight of the Osiris") / Manabu ("Beyond") (voice)

Pamela Adlon

Thadeus ("Final Flight of Osiris") / Cop ("Kid's Story") / Agent #2 ("World Record")

Kevin Michael Richardson

Alexa ("Matriculated") (voice)

Melinda Clarke

Crew Man ("Final Flight of the Osiris") / Kaiser ("Program") (voice)

John DiMaggio

Operator ("Final Flight of Osiris")

Tom Kenny

Pilot ("Final Flight of Osiris")

Rick Gomez

Crew Woman ("Final Flight of Osiris") / Nurse ("World Record") / Misha ("Beyond")

Tara Strong

Old Woman ("Final Flight of Osiris")

Bette Ford

01 Versatran Spokesman ("The Second Renaissance Part I & II")

Dane A. Davis

Mother ("The Second Renaissance Part I & II")

Jill Talley

The Instructor ("The Second Renaissance Part I & II") / Narrator ("World Record")

Julia Fletcher

Kid ("The Second Renaissance Part I & II")

Debi Derryberry

Additional Voices ("The Second Renaissance Part I & II") / Monaka ("Matriculated")

Dwight Schultz

Teacher ("Kid's Story")

John DeMita

Cis ("Program") / Yoko ("Beyond")

Hedy Burress

Duo ("Program")

Phil LaMarr

Dan ("World Record")

Victor Williams

Dan's Dad ("World Record")

John Wesley

Tom ("World Record")

Alex Fernandez

Reporter ("World Record")

Allison Smith

Agent #1 ("World Record") / Agent ("Beyond") / Agent ("A Detective Story")

Matt McKenzie

Housewife ("Beyond") / Kenny ("Beyond")

Tress MacNeille

Pudgy ("Beyond") / Masa ("Beyond") / Sara ("Beyond")

Kath Soucie

Clarence ("A Detective Story")

Terrence 'T.C.' Carson

Chyron ("Matriculated")

Rodney Saulsberry

Rox ("Matriculated")

Olivia D'Abo

Sandro ("Matriculated")

Jack Fletcher

Thadeus (voice)

Akio Otsuka