Neo

Keanu Reeves

Trinity

Carrie-Anne Moss

Ash/Raul/Miscellaneous voices

James Arnold Taylor

The Kid (voice)

Clayton Watson

Thadeus ("Final Flight of Osiris") / Cop ("Kid's Story") / Agent #2 ("World Record")

Kevin Michael Richardson

Jue ("Final Flight of the Osiris") / Manabu ("Beyond") (voice)

Pamela Adlon

Crew Man ("Final Flight of the Osiris") / Kaiser ("Program") (voice)

John DiMaggio

Alexa ("Matriculated") (voice)

Melinda Clarke

Operator ("Final Flight of Osiris")

Tom Kenny

Pilot ("Final Flight of Osiris")

Rick Gomez

Crew Woman ("Final Flight of Osiris") / Nurse ("World Record") / Misha ("Beyond")

Tara Strong

Bette Ford

01 Versatran Spokesman ("The Second Renaissance Part I & II")

Dane A. Davis

Old Woman ("Final Flight of Osiris")

Bette Ford

Mother ("The Second Renaissance Part I & II")

Jill Talley

The Instructor ("The Second Renaissance Part I & II") / Narrator ("World Record")

Julia Fletcher

Kid ("The Second Renaissance Part I & II")

Debi Derryberry

Additional Voices ("The Second Renaissance Part I & II") / Monaka ("Matriculated")

Dwight Schultz

Teacher ("Kid's Story")

John DeMita

Cis ("Program") / Yoko ("Beyond")

Hedy Burress

Duo ("Program")

Phil LaMarr

Dan ("World Record")

Victor Williams

Dan's Dad ("World Record")

John Wesley

Tom ("World Record")

Alex Fernandez

Reporter ("World Record")

Allison Smith

Agent #1 ("World Record") / Agent ("Beyond") / Agent ("A Detective Story")

Matt McKenzie

Housewife ("Beyond") / Kenny ("Beyond")

Tress MacNeille

Pudgy ("Beyond") / Masa ("Beyond") / Sara ("Beyond")

Kath Soucie

Clarence ("A Detective Story")

Terrence 'T.C.' Carson

Chyron ("Matriculated")

Rodney Saulsberry

Rox ("Matriculated")

Olivia d'Abo

Sandro ("Matriculated")

Jack Fletcher

Thadeus (voice)

Akio Otsuka

Director

Andy Jones

Director

Andrew R. Jones

Director

Andy Jones

Director

Yoshiaki Kawajiri

Director

Peter Chung

Director

Takeshi Koike

Director

Mahiro Maeda

Director

Kouji Morimoto

Director

Shinichirô Watanabe