Bartleby/Barry

Ben Affleck

Bethany Sloane

Linda Fiorentino

Loki/Larry

Matt Damon

Cardinal Ignatius

George Carlin

Serendipity

Salma Hayek

Jay

Jason Mewes

Rufus

Chris Rock

Metatron

Alan Rickman

Azrael

Jason Lee

Silent Bob

Kevin Smith

God

Alanis Morissette

John Doe Jersey

Bud Cort*

John Doe Jersey/God the Man

Bud Cort

Clinic Girl

Janeane Garofalo

Gun Salesman

Jeff Anderson

Grant Hicks

Brian O'Halloran

Kane

Dwight Ewell

Protestor #2

Walt Flanagan

Whitland

Mark Joy

Nun

Betty Aberlin

Smooching Seaman

Scott Mosier

Stygian Triplet

Barrett Hackney

St. Stephen's Priest

Dan Etheridge

Stygian Triplet

Jared Pfennigwerth

Mrs. Reynolds

Nancy Bach

Stygian Triplet

Kitao Sakurai

Bus Station Attendant

Guinevere Turner

Nun

Betty Amberlin

Protestor No. 1

Bryan Johnson

Gangster #1

Benjamin Cain

Protestor No. 2

Walter Flanagan

Waiter

Armando Rodriguez

Governor Dalton

Nancy Mosser

Gangster No. 2

Richard Baderinwa

Norman (Voice)

Ethan Suplee

Gangster No. 3

Javon Johnson

Gangster No. 4

Derrick Sanders

Blanket Boy on Train

Jon Gordon

Bartender

Matthew Maher

Officer McGee

Robert 'Ratface' Holtzman

Clinic Girl

Marie Elena O'Brien

Seaman Smoocher

Monica Hampton

Gangster #1

Benjamin J. Cain Jr.

Director

Kevin Smith