Jenifer Estess

Laura San Giacomo

Balerie Estess

Jane Kaczmarek

Meredith

Annabella Sciorra

Julianne Hoffenberg

Maddie Corman

Marilyn Estess

Jane Alexander

Jack

Vincent Spano

Nurse Vandemal

Camryn Manheim

Jenifer's Psychiatrist

Julianna Margulies

Wheelchair Saleswoman

Edie Falco

Herself

Donna Hanover

Nina Capelli

Marisa Tomei

Dr. Richard Feldman

Rob Morrow

Jenifer's Date

Scott Wolf

Scotty

Reed Rudy

Dr. Richards

Cedric Smith

Dr. Aaron Sanders

Fisher Stevens

Daniel Magder

Jane (Age 3)

Alex Gaistman

Michael

Bradley White

Meredith (Age 11)

Mallory Margel

Peter

Colin Ferguson

Lorna

Karen Robinson

Neurologist

Jason Blicker

Researcher

Robert Bockstael

Jenifer's Father (as Chris Bondy)

Christopher Bondy

Bus Driver

Johnie Chase

Impatient Passenger

David Eisner

Valerie (Age 14)

Imogen Haworth

Fire Marshal

Jim McAleese

Waiter

Dean Mckenzie

Amy

Nadia-Leigh Nascimento

Doctor #2

Dave Nichols