Mom

Megan Cavanagh

James 'Jimmy' Isaac Neutron (voice)

Debi Derryberry

Dad

Mark DeCarlo

King Goobot V (voice)

Patrick Stewart

Steve Oedekerk

David N. Weiss

Ooblar (voice)

Martin Short

Sheen Estevez

Jeff Garcia

Newscaster

Bob Goen

Newscaster

Mary Hart

Ms. Winfred Fowl (voice)

Andrea Martin

Ultra Lord / Mission Control / General Bob (voice)

Jim Cummings

Cindy

Carolyn Lawrence

Goddard/Orthgot/Worm/Demon

Frank Welker

Nick

Candi Milo

Carl Wheezer / Mr. and Mrs. Wheezer / Kid in Classroom (voice)

Rob Paulsen

Libby

Crystal Scales

Hostess (voice)

Laraine Newman

Yokian Guard / Gus (voice)

David L. Lander

Mr. Estevez (voice)

Carlos Alazraqui

Zachery / Reporter / Angie

Kimberly Brooks

Bobby / Kid / Control Yokian (voice)

Keith Alcorn

Guard

Paul Greenberg

Bobby's Twin Brother (voice) / Butch (voice) / Jailbreak Cop (voice)

Billy West

Little Girl / Camera Person (voice)

Jeannie Elias

Chris (voice)

Michael Hagiwara

Norad Officer (voice)

Dee Bradley Baker

Octapuke Kid/Guard/Bennie

John A. Davis

Digital Voice (voice)

Richard Allen

Screamer (voice)

Brian Capshaw

Screamer (voice)

Cheryl Ray

Yokian Incubator Operator (voice)

Mark Menza

Hyperactive Kid / Arena Yokian (voice)

Matthew Russell