Professor Sherman Klump/Clesius "Papa" Klump/Young Clesius Klump/Mama Klump/Ernie Klump/Grandma Klump/Buddy Love/Lance Perkins

Eddie Murphy

Professor Denise Gaines

Janet Jackson

Dean Richmond

Larry Miller

Jason

John Ales

Mr. Gaines

Richard Gant

Denise's Mother

Anna Maria Horsford

Leanne Guilford

Melinda McGraw*

Leanne Guilford

Melinda McGraw

Ernie Klump Jr.

Jamal Mixon

Isaac

Gabriel Williams

Restaurant Manager

Chris Elliott

Restaurant Trainee

Duffy Taylor

Dr. Knoll

Earl Boen

Bright Student

Nikki Cox

Dr. Knoll

Earl Boen

Claudine

Freda Payne

Old Willie

Sylvester Jenkins

Chantal

Wanda Sykes

Stripper

George King

Preacher

Charles Walker*

Bridesmaid

Enya Flack

Party Guest / Bridesmaid

Andrea C. Robinson

Bridesmaid

Rainell Saunders

Mrs. Dudikoff

Selma Stern

Receptionist

Julia Schultz

Party Guest

Kym Whitley

Man in Bathroom

Barry W. Blaustein

Man in Bathroom

David Sheffield

Zeke

Ralph Drischell

Baby Buddy

Myles Mason

Baby Buddy

Jeffrey Michael Freeman

Baby Buddy

Maurice Colquitt

Boardroom Member

Bill Applebaum

Boardroom Member

Harry S. Murphy

Guy in Elevator

Tom Jourden

Dancer

Shawnette Heard

Dancer

Kelly Konno

Dancer

Laurie Sposit

Dancer

Nadine Ellis

Buddy at 15

Kevin Michael Mondane

Sweet Old Lady with Dog

Viola Kates Stimpson

Buxom Student

Naomi Kale

Fraternity Student

Kente Scott

Lecture Student

Justin Urich

Buxom Student

Naomi Morales

Heavyset Woman

Sonya Eddy

Krusty Reporter

James D. Brubaker

Cab Driver

Richie Palmer

Four Star General

Charles Napier

Scientist

Steve Kehela

Scientist

Miguel A. Nunez Jr.

Dog Owner

Renee Tenison

American Newscaster

Richard Saxton

Scientist

Miguel A. Núñez

Scared Popcorn Man

Peter Segal

Scared Popcorn Man

William Kerr

Scared Hot Dog Vendor

Michael Ewing

Scared Little Girl

Nicole Segal

Scared Little Girl

Nikki Segal

Boardroom Member

Harry Murphy

Director

Brian Grazer

Director

Peter Segal