Professor Sherman Klump/Clesius "Papa" Klump/Young Clesius Klump/Mama Klump/Ernie Klump/Grandma Klump/Buddy Love/Lance Perkins
Eddie Murphy
Professor Denise Gaines
Janet Jackson
Dean Richmond
Larry Miller
Jason
John Ales
Mr. Gaines
Richard Gant
Denise's Mother
Anna Maria Horsford
Leanne Guilford
Melinda McGraw*
Leanne Guilford
Melinda McGraw
Ernie Klump Jr.
Jamal Mixon
Isaac
Gabriel Williams
Restaurant Manager
Chris Elliott
Restaurant Trainee
Duffy Taylor
Dr. Knoll
Earl Boen
Bright Student
Nikki Cox
Dr. Knoll
Earl Boen
Claudine
Freda Payne
Old Willie
Sylvester Jenkins
Chantal
Wanda Sykes
Stripper
George King
Preacher
Charles Walker*
Bridesmaid
Enya Flack
Party Guest / Bridesmaid
Andrea C. Robinson
Bridesmaid
Rainell Saunders
Mrs. Dudikoff
Selma Stern
Receptionist
Julia Schultz
Party Guest
Kym Whitley
Man in Bathroom
Barry W. Blaustein
Man in Bathroom
David Sheffield
Zeke
Ralph Drischell
Baby Buddy
Myles Mason
Baby Buddy
Jeffrey Michael Freeman
Baby Buddy
Maurice Colquitt
Boardroom Member
Bill Applebaum
Boardroom Member
Harry S. Murphy
Guy in Elevator
Tom Jourden
Dancer
Shawnette Heard
Dancer
Kelly Konno
Dancer
Laurie Sposit
Dancer
Nadine Ellis
Buddy at 15
Kevin Michael Mondane
Sweet Old Lady with Dog
Viola Kates Stimpson
Buxom Student
Naomi Kale
Fraternity Student
Kente Scott
Lecture Student
Justin Urich
Buxom Student
Naomi Morales
Heavyset Woman
Sonya Eddy
Krusty Reporter
James D. Brubaker
Cab Driver
Richie Palmer
Four Star General
Charles Napier
Scientist
Steve Kehela
Scientist
Miguel A. Nunez Jr.
Dog Owner
Renee Tenison
American Newscaster
Richard Saxton
Scientist
Miguel A. Núñez
Scared Popcorn Man
Peter Segal
Scared Popcorn Man
William Kerr
Scared Hot Dog Vendor
Michael Ewing
Scared Little Girl
Nicole Segal
Scared Little Girl
Nikki Segal
Boardroom Member
Harry Murphy