Scooby-Doo / Fred Jones (voice)

Frank Welker

Shaggy Rogers (voice)

Matthew Lillard

Velma

Mindy Cohn

Daphne Blake (voice)

Grey DeLisle

Rick Yantz/Announcer/Hospital PA

Dave "Gruber" Allen

Kriegstaffebot (Voice) / Gene Shepherd (voice) / Junk (voice)

Dee Bradley Baker

Ernesto/Todd

Carlos Alazraqui

Dr. Henklefust

John Billingsley

Nova

Amy Acker

Luna

Kimberly Brooks

Eager Clerk/Clerk's Pet

Eric Bauza

Dreamweaver (voice) / Curator Vronsky (voice) / Krod (voice)

Troy Baker

Mary-Ann Geerdon/Tiffany

Isabella Acres

Captain Caveman

Jim Cummings

Professor Horatio Kharon

Michael J. Anderson

Older Danny Darrow

Dwight Schultz

Mr. E (voice) / Mr. E (voice) / Mr. E

Lewis Black

Sheila Altoonian

Beverly D'Angelo

Dead Justice

Powers Boothe

Bud Coleman

David Faustino

Gary (voice) / Gary / Referee #2 (voice)

Tony Cervone

Arthur Baywosenthal

Zach Callison

Angel Dynamite (voice) / Cassidy Williams (voice) / Cassidy Williams

Vivica A. Fox

Marcie 'Hot Dog Water' Fleach (voice) / Marcy 'Hot Dog Water' Fleach (voice) / Hot Dog Water (voice)

Linda Cardellini

Sheriff Bronson Stone (voice) / Sheriff Stone (voice)

Patrick Warburton

Professor Enrique Andelusossa

Christian Lenz

H.P. Hatecraft

Jeffrey Combs

Charles "Cachinga" Wheatlesby/Destroido Computer

Greg Ellis

Hugh Dederdee

Joe Holt

Daniel Prezette/Frantzee Pantz/Gus Boggs

Quinton Flynn

Dan Fluunk/Fiend

Kevin Michael Richardson

Younger Danny Darrow

Will Shadley

Mayor Janet Nettles (voice) / Principal Quinlan (voice)

Kate Higgins

Garden Manager/Maitre D'

Kevin Dunn

Evallo Von Meanskrieg

Chris Hardwick

Mayor Fred Jones Sr. (voice) / Mayor Fred Jones Sr. / Motorcycle Cop (voice)

Gary Cole

Granny Snaggletooth

Laraine Newman

Angie Dinkley (voice) / Mrs. Dinkley (voice)

Frances Conroy

Lady Marmalade

Cree Summer

Weena/Waitress

April Winchell

Thorn

Jennifer Hale

Ed Machine/Announcer/Creepy Voice

Richard McGonagle

Ruby Stone

Florence Henderson

Professor Pericles (voice)

Udo Kier

Chen/Red Wizard

James Hong

Marion Spartan

Julie Bowen

Young Man/Ben

David Markus

Nibiru

Clancy Brown

Picnicker

Clyde Kusatsu

Funky Phantom/Chairman

Tom Kenny

Fernando El Aguirre

Christian Lanz

Harry Schnesle-Boysen

David Juskow

Grandma Moonbeam

Marion Ross

Gunther Gator

Billy West

Vincent Van Ghoul (voice)

Maurice LaMarche

Race Bannon/Bobo

Christopher Corey Smith

Jason

Daryl Sabara

Skipper's Brother

Daran Norris

Aphrodite/Amanda Smyth

Tricia Helfer

Skipper Shelton (voice)

John O'Hurley

Mai Le

Stephanie Sheh

Melvin Keisterbaum

Phil LaMarr

Himself

Harlan Ellison

Crybaby Clown

Mark Hamill

Dandy Highwayman

James Marsters

Winslow Fleach

Rob Paulsen

Colton Rogers

Casey Kasem

Dr. Rick Spartan

James Patrick Stuart

Frau Gluck

Mindy Sterling

Mr. Wang/White Wizard

George Takei

Demon Dog

Fred Tatasciore

Peter Trickell

George Segal

Grady Gator/Delivery Guy

John DiMaggio

George Avocados (voice) / George Avocados / Rung Ladderton

James Arnold Taylor

Gill Littlefoot

Jeffrey Tambor

Kelsepsian/Jingle Singer/Hairy Sasquach

Paul Rugg

Gabtraf

Phil Idrissi

Brad Chiles (voice)

Tim Matheson

Judy Reeves (voice) / Amy (voice)

Tia Carrere

Herself

Martha Quinn

Nan Blake (voice)

Kath Soucie

Professor Emmanuel Raffalo/Tourist

Jeff Bennett

Dr. Cavanaugh

Gary Anthony Williams

Odnarb

Ben McKenzie

Lord Infernicus/Boo

Rick Wasserman

Jason's Mom

Jessica Walter

Baylor Hotner

Matt Lanter

Ben/Rhino/Cook/Howard E. Robertson

Crispin Freeman

Brenda

Beth Tapper

Lord Barry

Lloyd Sherr

Dad

David Kaye

Alice May

Hynden Walch

Ned Fussbuster

Charles Shaughnessy

Dusk

Jane Wiedlin

J.R. Kipple

Jim Rash

Horbert Feist

Jason Marsden

Gorgeous G

Roz Ryan

Queen Amanda

Audrey Wasilewski

Ethan (voice) / Farmer (voice)

Mitch Watson

Judy Reeves/Regina Wentworth

Kari Wahlgren

Ricky Owens

Scott Menville

Brad Chiles

Nolan North

Director

Doug Murphy

Director

Curt Geda

Director

Victor Cook

Director

Lauren Montgomery

Director

Michael Goguen