Dr. John Dolittle

Robert Downey Jr.

King Rassouli

Antonio Banderas

Tommy Stubbins

Harry Collett

Dr. Blair Müdfly

Michael Sheen

Lord Thomas Badgley

Jim Broadbent

Queen Victoria

Jessie Buckley

Chee-Chee (voice)

Rami Malek

Poly

Emma Thompson

Lily Dolittle

Kasia Smutniak

Lady Rose

Carmel Laniado

Arnall Stubbins

Ralph Ineson

Yoshi (voice)

John Cena

Bethan Stubbins

Joanna Page

Plimpton

Kumail Nanjiani

Kevin (voice)

Craig Robinson

Dab-Dab (voice)

Octavia Spencer

Arnall Stubbins Jr.

Sonny Ashbourne Serkis

Sir Gareth

Oliver Chris

Barry (voice)

Ralph Fiennes

Jip

Tom Holland

Archbishop

Clive Francis

Navy Man

Paul Holowaty

Betsy

Selena Gomez

Captain William Derrick

Elliot Barnes-Worrell

Tutu

Marion Cotillard

Lieutenant

Mark Umbers

Don Carpenterino

David Sheinkopf

Jeff the Prisoner

Sid Sagar

Postman

Martin Pemberton

Dragon

Frances de la Tour

Nick A. Fisher

James the Dragonfly (voice)

Jason Mantzoukas

Clyde

Matt King

Pirate

Samson Kayo

Pirate / Animal Performer

John-Luke Roberts

Prisoner

Joseph Balderrama

Prisoner

Daniel Hoffmann-Gill

Animal Performer

Jane Leaney

On Set Chee-Chee / Animal Performer

Josh Jefferies

On Set Yoshi / Animal Performer

Shaun McKee

Pirate/Animal Performer

John Luke Robertson

Courtier

Georgie-May Tearle

Humphrey the Whale (voice)

Tim Treloar

Beard Mouse and Leona (voice)

Jim Carretta

Mini the Sugar Glider (voice)

Nick Fisher

Mouse (voice)

Ranjani Brow

Mouse (voice)

Kelly Stables

Army Ant (voice)

Scott Menville

Baby Animal (voice)

Gia Davis

Baby Animal (voice)

Henry Holcomb

Baby Animal (voice)

Kyrie McAlpin

Baby Animal (voice)

Isley Zamora

Pirate

Stewart Scudamore

Tobias Meister

Marcus Off

Monica Bielenstein

Bastian Sierich

Animal Performer

Richard Soames

Rabbit (voice) (uncredited)

Will Arnett

Udo Schenk

Patrizia Carlucci