Dr. John Dolittle
Robert Downey Jr.
King Rassouli
Antonio Banderas
Dr. Blair Müdfly
Michael Sheen
Lord Thomas Badgley
Jim Broadbent
Queen Victoria
Jessie Buckley
Tommy Stubbins
Harry Collett
Poly
Emma Thompson
Lily Dolittle
Kasia Smutniak
Lady Rose
Carmel Laniado
Chee-Chee
Rami Malek
Arnall Stubbins
Ralph Ineson
Yoshi (voice)
John Cena
Bethan Stubbins
Joanna Page
Plimpton (voice)
Kumail Nanjiani
Dab-Dab (voice)
Octavia Spencer
Arnall Stubbins Jr.
Sonny Ashbourne Serkis
Jip
Tom Holland
Sir Gareth
Oliver Chris
Kevin
Craig Robinson
Archbishop
Clive Francis
Barry
Ralph Fiennes
Navy Man
Paul Holowaty
Betsy
Selena Gomez
Captain William Derrick
Elliot Barnes-Worrell
Tutu (voice)
Marion Cotillard
Lieutenant
Mark Umbers
Don Carpenterino
David Sheinkopf
Jeff the Prisoner
Sid Sagar
Postman
Martin Pemberton
Dragon (voice)
Frances de la Tour
Nick A. Fisher
James the Dragonfly
Jason Mantzoukas
Clyde
Matt King
Pirate
Samson Kayo
Pirate / Animal Performer
John-Luke Roberts
Prisoner
Joseph Balderrama
Prisoner
Daniel Hoffmann-Gill
Animal Performer
Jane Leaney
On Set Chee-Chee / Animal Performer
Josh Jefferies
On Set Yoshi / Animal Performer
Shaun McKee
Pirate/Animal Performer
John Luke Robertson
Courtier
Georgie-May Tearle
Humphrey the Whale (voice)
Tim Treloar
Beard Mouse and Leona (voice)
Jim Carretta
Mini the Sugar Glider (voice)
Nick Fisher
Mouse (voice)
Ranjani Brow
Mouse (voice)
Kelly Stables
Army Ant (voice)
Scott Menville
Baby Animal (voice)
Gia Davis
Baby Animal (voice)
Henry Holcomb
Baby Animal (voice)
Kyrie McAlpin
Baby Animal (voice)
Isley Zamora
Tobias Meister
Pirate
Stewart Scudamore
Marcus Off
Monica Bielenstein
Bastian Sierich
Animal Performer
Richard Soames
Udo Schenk
Patrizia Carlucci