Ivy

Gena Rowlands

Misha Vilyenkov

Tony Shalhoub

Ignacio

Cheech Marin

Dr. Reingold

Bruce Davison

Benny/Voice of Paulie

Jay Mohr

Adult Marie Alweather

Trini Alvarado

Artie

Buddy Hackett

Marie Alweather

Hallie Kate Eisenberg

Warren Alweather

Matt Craven

Lila Alweather

Laura Harrington

Virgil the Janitor

Bill Cobbs

Ruby / Lupe (voice)

Tia Texada

Gerald

Charles Parks

Graduate Student #1

Peter Basch

Grandpa

Hal Robinson

Graduate Student #2

Emily Mura-Smith

Speech Therapist

Tamara Zook

Jeremy

Seth Mumy

Shirley

Nicole Chamberlain

Molly

Francesca Federico-O'Murchu

Mr. Tauper

Jerry Winsett

Research Assistant No. 1

Dig Wayne

Research Assistant No. 2

Michael Leydon Campbell

Veterinarian No. 2

Kristie Transeau

Ivy's Doctor

Bud Cox

Cantina Singer

Josh Cruze

Bruce Davidson