Mrs. Gertrude "Trudy" Lintz

Rene Russo

Dr. Bill Lintz

Robbie Coltrane

Dick Croner, Trudy's Assistant

Alan Cumming

Emma, Lintz's Maid

Irma P. Hall

Professor Spatz

Paul Reubens

Mr. Joe Bowman

John Aylward

Adult Buddy

Peter Elliott

Mrs. Bunny Bowman

Mimi Kennedy

Juvenile and Adult Buddy Puppeteer

Mak Wilson

Theater-goer

Jon Simmons

Minister

Philip Baker Hall

Fair Cop

Dane Cook

Movie Woman

Kathleen Klein

Skinny Man

Michael Reid MacKay

Usher

Russell Young

Zoo Keeper

Frank Collison

Policeman

John Ennis

Buddy (voice)

Frank Welker

Barker

Al Weber

Buddy (voice)

Gary A. Hecker

Bellowing Man

Kyle Galyean

Barker

Al 'Red Dog' Weber

Policeman

Jeff Hatz

Ali Baba

Bradley J. Lesley

Cornered Woman

Julianna Wheeler

Buddy

Lynn Robertson Bruce

Buddy

Mark Sealey

Buddy

Rob Tynger

Buddy

Michelan Sisti

Buddy

Peter Hurst

Buddy

Leif Tilden

Buddy

Star Townshend

Buddy Vocals

Hector C. Gika

Robert Tygner

Star Townsend