Madison Mitchell
Annabelle Wallis
George Young
Maddie Hasson
Michole Briana White
George Young
Dr. Florence Weaver
Jacqueline McKenzie
Mrs. Ryerson
Rachel Winfree
Regina Moss
Michole Briana White
Paul Mabon
Marina Mazepa
Jane Doe/Serena
Jean Louisa Kelly
Emir García
Ingrid Bisu
Jeanne
Susanna Thompson
Dr. Gregory
Amir Aboulela
Derek Mitchell
Jake Abel
Seattle Police Officer/Killed Detective
Gregory Garcia
Dr. Victor Fields
Christian Clemenson
Jeanne
Susanna Thompson*
Mendez
Mercedes Colon
Officer Rubin
Ruben Pla
Basco
Dan Ramos
Nurse Annie
Natalia Safran
Officer Lee
Jon Lee Brody
Hospital Security Guard #1
Mike Mendez
Beverly
Paula Marshall
Research Doctor
Jesus Trujillo
Scorpion
Zoë Bell
News Anchor
Danielle Nottingham
Henry McKenzie
Beta
Shaunte Lynette Johnson
Hospital Security Guard #2
Randy Haynie
Hospital Security Guard #3
Cord Walker
Research Orderly
Lisa Catara
Gabriel (voice)
Ray Chase
Mr. Stanley
Patrick Cox
Young Madison
Mckenna Grace
Young Serena
Madison Wolfe
Orderly
Paul Mabon
Frank
Andy Bean
Nurse Velasquez
Patricia Velásquez