Madison Mitchell

Annabelle Wallis

George Young

Maddie Hasson

Michole Briana White

George Young

Dr. Florence Weaver

Jacqueline McKenzie

Mrs. Ryerson (uncredited)

Rachel Winfree

Regina Moss

Michole Briana White

Paul Mabon

Marina Mazepa

Jeanne

Susanna Thompson

Jane Doe/Serena

Jean Louisa Kelly

Emir García

Ingrid Bisu

Dr. Gregory

Amir Aboulela

Derek Mitchell

Jake Abel

Seattle Police Officer/Killed Detective

Gregory Garcia

Dr. Victor Fields

Christian Clemenson

Mendez

Mercedes Colon

Officer Rubin

Ruben Pla

Basco

Dan Ramos

Nurse Annie

Natalia Safran

Officer Lee

Jon Lee Brody

Hospital Security Guard #1

Mike Mendez

Beverly

Paula Marshall

Research Doctor

Jesus Trujillo

Scorpion

Zoë Bell

News Anchor

Danielle Nottingham

Beta

Shaunte Lynette Johnson

Henry McKenzie

Hospital Security Guard #2

Randy Haynie

Hospital Security Guard #3

Cord Walker

Research Orderly

Lisa Catara

Gabriel (voice)

Ray Chase

Young Madison

Mckenna Grace

Mr. Stanley (uncredited)

Patrick Cox

Young Serena

Madison Wolfe

Orderly (uncredited)

Paul Mabon

Frank

Andy Bean

Nurse Velasquez

Patricia Velásquez

Nurse J. De Marco (uncredited)

Janet Hsieh

Seattle Police Officer (uncredited)

Gino Montesinos

Referee (uncredited)

Josh Rutgers

Seattle Police Officer (uncredited)

Kalina Vanska

Prisoner (uncredited)

Christina Veronica