Owen/Ned 'Little Ned' Lift/Cousin Paddy

Danny DeVito

Larry Donner

Billy Crystal

Beth Ryan

Kim Greist

Mrs. Lift

Anne Ramsey

Margaret Donner

Kate Mulgrew

Lester

Branford Marsalis

Joel

Rob Reiner

Detective DeBenedetto

Bruce Kirby

Sargeant

Joey DePinto

Oprah Winfrey

Oprah Winfrey

Mrs. Hazeltine

Annie Ross

Pinsky

Raye Birk

Ms. Gladstone

Olivia Brown

Mr. Perlman

Philip Perlman

Ramon

Stu Silver

Millington

J. Alan Thomas

Bucky

Randall Miller

Rosey

Andre Rosey Brown

Mr. Lopez

Tony Ciccone

Steward

William Ray Watson

Announcer

Larry McCormick

Old Man

Peter Brocco

Reporter

Hettie Lynne Hurtes

Laughing Woman

Karen J. Westerfield

Cab Driver

Stanley L. Gonsales

Priest

Fred Gephart

Jazz Band Member

Billy Childs

Jazz Band Member

Tony Dumas

Radio DJ (voice)

Don Burns

Jazz Band Member

Ralph Penland

Momma

Anne Ramsay

Sergeant

Joey De Pinto