Pablo Rodriguez (voice)
Ricardo El Mandril Sanchez
Manolo
Diego Luna
Additional Voices (voice)
Jose Alvarez
Maria
Zoë Saldana
Joaquin
Channing Tatum
The Candle Maker
Ice Cube
Mary Beth (voice)
Christina Applegate
Xibalba
Ron Perlman
Chato (voice)
Eugenio Derbez
La Muerte
Kate del Castillo
Pancho Rodriguez (voice)
Cheech Marin
Pepe Rodriguez (voice)
Gabriel Iglesias
Jorge
Placido Domingo
Carlos Sanchez
Héctor Elizondo
Carmen
Ana de la Reguera
Chakal (voice)
Dan Navarro
Pablo Rodriguez
Ricardo Sanchez
Luis
Danny Trejo
General Posada / Dali / Chuy (voice)
Carlos Alazraqui
Grandma
Grey Griffin
Young Joaquin
Elijah Rodriguez
Young Manolo (voice)
Emil-Bastien Bouffard
Young Maria (voice)
Genesis Ochoa
Goth Kid / Orphan
Trey Bumpass
Sasha (As Kennedy 'KK' Peil)
Kennedy Peil
Adelita / Nina (voice)
Anjelah Johnson-Reyes
Land of the Remembered Captain (voice)
Miguel Sandoval
Scardelita (voice)
Sandra Equihua
Goya / Dali (voice)
Ben Gleib
Ignacio (voice)
Gunnar Sizemore
Sister Ana (voice)
Angélica María
Father Domingo / Cave Guardian (voice)
Eric Bauza
Sanjay
Ishan Sharma
Skeleton Carmelo (voice)
Jorge R. Gutierrez
Claudia (voice)
Sandra Echeverría
La Muerte as Old Woman (voice)
Tonita Castro
Old Man Hemingway (voice)
Troy Evans
Jane (voice)
Callahan Clark
Thomas (voice)
Aron Warner
Land of the Remembered Captain's Wife (voice)
Guillermo Del Toro
Conductor (voice)
Brad Booker
Additional Voices (voice)
Rosemary Alexander
Additional Voices (voice)
Steve Alterman
Additional Voices (voice)
Eva Bella
Additional Voices (voice)
Madison Carlon
Additional Voices (voice)
Vicki Davis
Additional Voices (voice)
Moosie Drier
Additional Voices (voice)
Cullen McCarthy
Additional Voices (voice)
David Michie
Additional Voices (voice)
Michelle Moores
Additional Voices (voice)
Jonathan Nichols
Additional Voices (voice)
Al Rodrigo
Additional Voices (voice)
Marcelo Tubert
Additional Voices (voice)
Lynnanne Zager
Additional Voices (voice)
Ruth Zalduondo
Additional Voices (voice)
Newell Alexander
Additional Voices (voice)
David Cowgill
Additional Voices (voice)
Elisa Gabrielli
Additional Voices (voice)
Richard Miro
Additional Voices (voice)
Arthur Ortiz
Additional Voices (voice)
Nathaniel Semsen